Milk makes lysosomes lethal Journal Article
| Authors: | Krishna, S.; Overholtzer, M. |
| Article Title: | Milk makes lysosomes lethal |
| Abstract: | Stat3 has been shown to regulate lysosome membrane permeabilization and cell death in vivo during post-lactation mammary gland involution. It is now revealed that Stat3 induces lysosome membrane permeabilization by causing phagocytosis of milk fat globules, which destabilize the lysosome membrane leading to leakage of cathepsin proteases. |
| Keywords: | signal transduction; protein expression; review; nonhuman; stat3 protein; apoptosis; protein degradation; regulatory mechanism; breast epithelium; triacylglycerol; cathepsin; proteinase; phagocytosis; involution; lactation; lysosome membrane; cell membrane permeability; cytochrome c; lysosome associated membrane protein 2; in vivo culture; human; milk fat |
| Journal Title: | Nature Cell Biology |
| Volume: | 16 |
| Issue: | 11 |
| ISSN: | 1465-7392 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2014-11-01 |
| Start Page: | 1029 |
| End Page: | 1031 |
| Language: | English |
| DOI: | 10.1038/ncb3059 |
| PROVIDER: | scopus |
| PUBMED: | 25358350 |
| DOI/URL: | |
| Notes: | Export Date: 1 December 2014 -- Source: Scopus |
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