Results of a prospective thyroid ultrasound screening program in adenomatous polyposis patients Journal Article


Authors: Steinhagen, E.; Hui, V. W.; Levy, R. A.; Markowitz, A. J.; Fish, S.; Wong, R. J.; Sood, R.; Ochman, S. M.; Guillem, J. G.
Article Title: Results of a prospective thyroid ultrasound screening program in adenomatous polyposis patients
Abstract: Conclusions A large proportion of adenomatous polyposis patients will have abnormal results on thyroid US, including suspicious-Appearing thyroid nodules that when biopsied are malignant. Female patients have an apparently greater risk of developing TC. Polyposis patients, especially women, should be offered participation in a thyroid US screening program. Background Patients with adenomatous polyposis may be at increased risk for developing thyroid cancer (TC). However, screening guidelines for TC in these patients are not well established. Methods Patients with a diagnosis of familial adenomatous polyposis, attenuated familial adenomatous polyposis, and gene mutation-negative adenomatous polyposis enrolled in our Hereditary Colorectal Cancer Family Registry were eligible for a screening thyroid ultrasound (US). Findings were reviewed by the study endocrinologist and intervention and/or follow-up determined. Results Fifty patients underwent screening thyroid US. Thirty-four (68%) patients had abnormal findings on US, including 27 (79%) with thyroid nodules. In 7 patients, US-detected thyroid nodules met established criteria for fine-needle aspiration. Of the 6 patients who underwent fine-needle aspiration, 2 (4%) were diagnosed with papillary TC. Both of these patients were female.
Keywords: thyroid cancer; adenomatous polyposis; screening for cancer prevention
Journal Title: American Journal of Surgery
Volume: 208
Issue: 5
ISSN: 0002-9610
Publisher: Elsevier Inc.  
Date Published: 2014-11-01
Start Page: 764
End Page: 769
Language: English
DOI: 10.1016/j.amjsurg.2014.03.012
PROVIDER: scopus
PUBMED: 25073656
DOI/URL:
Notes: Export Date: 1 December 2014 -- Source: Scopus
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MSK Authors
  1. Arnold J Markowitz
    110 Markowitz
  2. Jose Guillem
    384 Guillem
  3. Richard J Wong
    238 Wong
  4. Stephanie Anne Fish
    17 Fish
  5. Rachel Allison Levy
    3 Levy
  6. Vanessa W Hui
    7 Hui
  7. Rupa   Sood
    3 Sood
  8. Stephanie M Ochman
    1 Ochman