Comprehensive molecular characterization of gastric adenocarcinoma Journal Article
| Author: | The Cancer Genome Atlas Research Network |
| Contributors: | Schultz, N.; Shen, R.; Weinhold, N.; Kelsen, D. P.; Askoy, B. A.; Ciriello, G.; Dresdner, G.; Gao, J.; Gross, B.; Jacobsen, A.; Lee, W.; Ramirez, R.; Sander, C.; Senbabaoglu, Y.; Sinha, R.; Sumer, S. O.; Sun, Y.; Janjigian, Y. Y.; Cho, E.; Ladanyi, M.; Tang, L. |
| Article Title: | Comprehensive molecular characterization of gastric adenocarcinoma |
| Abstract: | Gastric cancer is a leading cause of cancer deaths, but analysis of molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project. We propose a molecular classification dividing gastric cancer into four subtypes: tumours positive for Epstein-Barr virus, which display recurrent PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2, CD274 (also known as PD-L1) and PDCD1LG2 (also known as PD-L2); microsatellite unstable tumours, which show elevated mutation rates, including mutations of genes encoding targetable oncogenic signalling proteins; genomically stable tumours, which are enriched for the diffuse histological variant and mutations of RHOA or fusions involving RHO-family GTPase-activating proteins; and tumours with chromosomal instability, which show marked aneuploidy and focal amplification of receptor tyrosine kinases. Identification of these subtypes provides a roalmap for patient stratification and trials of targeted therapies. |
| Keywords: | methylation; classification; gene-expression; kinase; somatic mutations; subtypes; exome; cancer; cell lymphomas; ebv-infection |
| Journal Title: | Nature |
| Volume: | 513 |
| Issue: | 7517 |
| ISSN: | 0028-0836 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2014-09-11 |
| Start Page: | 202 |
| End Page: | 209 |
| Language: | English |
| ACCESSION: | WOS:000341362800044 |
| DOI: | 10.1038/nature13480 |
| PROVIDER: | wos |
| PMCID: | PMC4170219 |
| PUBMED: | 25079317 |
| Notes: | Article -- Source: Wos |
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