Advances in clinical applications of tissue proteomics: Opportunities and challenges Journal Article
| Author: | Dogan, A. |
| Article Title: | Advances in clinical applications of tissue proteomics: Opportunities and challenges |
| Abstract: | Mass spectrometry (MS)-based proteomics assays provide unprecedented opportunities for determination of protein expression in tissues for clinical applications. Within the last few years a number of clinical assays have been established. These include multiplexed selected reaction monitoring based approaches to quantify protein targets of therapeutic agents in cancer tissues and bottom-up shotgun MS-based proteomics approaches to diagnose and classify protein deposition disorders such as amyloidosis. These examples highlight the vast potential of MS-based proteomics as analytical and descriptive tools for clinical diagnosis of human disease. However, a number of major challenges remain for broader application and acceptance of such technologies in routine clinical care. |
| Keywords: | mass spectrometry; immunoglobulin; amyloidosis; proteomics; transthyretin; cancer |
| Journal Title: | Expert Review of Proteomics |
| Volume: | 11 |
| Issue: | 5 |
| ISSN: | 1478-9450 |
| Publisher: | Informa Healthcare |
| Date Published: | 2014-10-01 |
| Start Page: | 531 |
| End Page: | 533 |
| Language: | English |
| DOI: | 10.1586/14789450.2014.953062 |
| PROVIDER: | scopus |
| PUBMED: | 25187078 |
| DOI/URL: | |
| Notes: | Export Date: 3 November 2014 -- Source: Scopus |
