Cell polarity pathways converge and extend to regulate neural tube closure Journal Article
| Authors: | Zohn, I. E.; Chesnutt, C. R.; Niswander, L. |
| Article Title: | Cell polarity pathways converge and extend to regulate neural tube closure |
| Abstract: | Neural tube defects, such as spinabifida, craniorachischisis and anencephaly, are some of the most common birth defects in humans. Recent studies in mouse model systems suggest that craniorachischisis is associated with mutations in genes that regulate cell polarity. Using Xenopus as a model system, Wallingford and Harland have now shed light on the mechanism by which these pathways affect neural tube closure. |
| Keywords: | mouse; gene; xenopus; defects; movements; neurulation; scribble; floor plate; loop-tail; vertebrate gastrulation |
| Journal Title: | Trends in Cell Biology |
| Volume: | 13 |
| Issue: | 9 |
| ISSN: | 0962-8924 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2003-09-01 |
| Start Page: | 451 |
| End Page: | 454 |
| Language: | English |
| ACCESSION: | WOS:000185311600002 |
| DOI: | 10.1016/s0962-8924(03)00173-9 |
| PROVIDER: | wos |
| PUBMED: | 12946622 |
| Notes: | Article -- Source: Wos |
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