Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2 Journal Article


Authors: King, M. C.; Marks, J. H.; Mandell, J. B.; The New York Breast Cancer Study Group
Contributors: Baum, R. C.; Borgen, P.; Brown, K. L.; Glogowski, E.; Haas, B. R.; Hampel, H.; McDermott, D. A.; Norton, L.; Pierce, H. H.; Pinto, M.; Robson, M.; Scheuer, L.; Schulz, C. J.; Offit, K.
Article Title: Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2
Abstract: Risks of breast and ovarian cancer were determined for Ashkenazi Jewish women with inherited mutations in the tumor suppressor genes BRCA1 and BRCA2. We selected 1008 index cases, regardless of family history of cancer, and carried out molecular analysis across entire families. The lifetime risk of breast cancer among female mutation carriers was 82%, similar to risks in families with many cases. Risks appear to be increasing with time: Breast cancer risk by age 50 among mutation carriers born before 1940 was 24%, but among those born after 1940 it was 67%. Lifetime risks of ovarian cancer were 54% for BRCA1 and 23% for BRCA2 mutation carriers. Physical exercise and lack of obesity in adolescence were associated with significantly delayed breast cancer onset.
Keywords: mastectomy; prevalence; penetrance; women; series; frequency; individuals; oophorectomy; family-history; ashkenazi jewish carriers
Journal Title: Science
Volume: 302
Issue: 5645
ISSN: 0036-8075
Publisher: American Association for the Advancement of Science  
Date Published: 2003-10-24
Start Page: 643
End Page: 646
Language: English
ACCESSION: WOS:000186119900059
DOI: 10.1126/science.1088759
PROVIDER: wos
PUBMED: 14576434
Notes: Article -- Source: Wos
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MSK Authors
  1. Kenneth Offit
    527 Offit
  2. Larry Norton
    593 Norton
  3. Mark E Robson
    383 Robson
  4. Robin Camhi Baum
    7 Baum
  5. Patrick I Borgen
    238 Borgen
  6. Lauren   Scheuer
    18 Scheuer
  7. Heather H Pierce
    6 Pierce
  8. Charlene J Schulz
    8 Schulz
  9. Mark D Pinto
    4 Pinto
  10. Bruce R Haas
    8 Haas