Authors: | Scaglioni, P. P.; Pandolfi, P. P. |
Article Title: | Taking apart a cancer protein |
Abstract: | Generation of a particular 'fusion' protein is characteristic of one type of leukaemia. But is it in fact the cleavage of this protein into smaller parts that is important? Provocative new findings suggest that it is. |
Keywords: | leukemia; oncoprotein; genetics; proteins; mouse; animal; metabolism; animals; mice; biological model; models, biological; protein degradation; neoplasm proteins; oncology; leukemia, promyelocytic, acute; protein processing; protein processing, post-translational; hybrid protein; tumors; leukemogenesis; tumor protein; promyelocytic leukemia; oncogene proteins, fusion; short survey; fusion proteins; medicine; cancer; humans; human; priority journal; article; promyelocytic leukemia retinoic acid receptor alpha fusion oncoprotein; promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; leukocyte elastase |
Journal Title: | Nature |
Volume: | 426 |
Issue: | 6966 |
ISSN: | 0028-0836 |
Publisher: | Nature Publishing Group |
Date Published: | 2003-12-04 |
Start Page: | 512 |
End Page: | 513 |
Language: | English |
DOI: | 10.1038/426512a |
PUBMED: | 14654828 |
PROVIDER: | scopus |
DOI/URL: | |
Notes: | Export Date: 25 September 2014 -- Source: Scopus |