Regulated recruitment and cooperativity in the design of biological regulatory systems Journal Article
| Author: | Ptashne, M. |
| Article Title: | Regulated recruitment and cooperativity in the design of biological regulatory systems |
| Abstract: | What distinguishes a man from a mouse is not so much different proteins, but rather the appearance of common proteins (etc.) at different times and positions in the developing organisms. Thus specific genes are transcribed or repressed, proteins degraded or stabilized, RNA transcripts spliced one way or another, and so on. These are examples of 'regulatory' decisions. A rather simple mechanism - called regulated recruitment - lies at the heart of many of these regulatory decisions. |
| Keywords: | signal transduction; genetics; proteins; metabolism; protein; physiology; gene expression regulation; gene activation; species specificity; species difference; feedback system; yeast; enzyme specificity; macromolecule; macromolecular substances; feedback, biochemical; gene expression regulation, enzymologic; yeasts; enzyme stability; synergy; enzyme activator; cooperative binding; article; enzyme activators; evolvability; regulated recruitment |
| Journal Title: | Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences |
| Volume: | 361 |
| Issue: | 1807 |
| ISSN: | 1364-503X |
| Publisher: | Royal Society |
| Date Published: | 2003-06-15 |
| Start Page: | 1223 |
| End Page: | 1234 |
| Language: | English |
| DOI: | 10.1098/rsta.2003.1195 |
| PUBMED: | 12816608 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
