On the synthesis of conformationally modified peptides through isonitrile chemistry: Implications for dealing with polypeptide aggregation Journal Article
| Authors: | Wu, X.; Park, P. K.; Danishefsky, S. J. |
| Article Title: | On the synthesis of conformationally modified peptides through isonitrile chemistry: Implications for dealing with polypeptide aggregation |
| Abstract: | A method for introducing a dimethyleneoxy constraint joining the N atoms of two consecutive amino acids in the context of a polypeptide has been developed. This constraint can profoundly affect the tendency of a polypeptide to suffer aggregation and desolubilization, and it can be readily removed under mild conditions. © 2011 American Chemical Society. |
| Journal Title: | Journal of the American Chemical Society |
| Volume: | 133 |
| Issue: | 20 |
| ISSN: | 0002-7863 |
| Publisher: | American Chemical Society |
| Date Published: | 2011-05-25 |
| Start Page: | 7700 |
| End Page: | 7703 |
| Language: | English |
| DOI: | 10.1021/ja2023898 |
| PROVIDER: | scopus |
| PUBMED: | 21539308 |
| PMCID: | PMC3108857 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: JACSA" - "Source: Scopus" |
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