Making and repairing the mammalian brain - In vitro production of dopaminergic neurons Journal Article

  


Authors: Perrier, A. L.; Studer, L.
Article Title: Making and repairing the mammalian brain - In vitro production of dopaminergic neurons
Abstract: Midbrain dopamine (DA) neurons play an essential role in modulating motor control, and their degeneration is the hallmark feature of Parkinson's disease (PD). In vitro production of DA neurons provides insight into the mechanisms that control cell fate choice, and offers an alternative to the use of fetal tissue for experimental cell replacement in PD. Here we will review the advantages and disadvantages of the various renewable cell sources and protocols tested, and discuss their relevance for basic studies and for cell therapy. © 2003 Elsevier Science Ltd. All rights reserved.
Keywords: review; nonhuman; mammalia; animals; stem cell transplantation; cell differentiation; neurons; stem cell; brain; mammal; stem cells; midbrain; mammals; nerve regeneration; dopamine; dopaminergic nerve cell; adoptive immunotherapy; differentiation; cell cloning; nerve growth; embryonic; neural; dopaminergic system; humans
Journal Title: Seminars in Cell and Developmental Biology
Volume: 14
Issue: 3
ISSN: 1084-9521
Publisher: Elsevier Inc.  
Date Published: 2003-06-01
Start Page: 181
End Page: 189
Language: English
DOI: 10.1016/s1084-9521(03)00010-7
PUBMED: 12948353
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0742322669&partnerID=40&md5=861dadff258b70197bdc71cf16dc79ca
Notes: Export Date: 25 September 2014 -- Source: Scopus
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MSK Authors
  1. Anselme Perrier
    8 Perrier
  2. Lorenz Studer
    220 Studer
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