Induced pluripotent stem cells: A tool for modeling Parkinson’s disease Review
| Authors: | Bose, A.; Petsko, G. A.; Studer, L. |
| Review Title: | Induced pluripotent stem cells: A tool for modeling Parkinson’s disease |
| Abstract: | Parkinson's disease (PD) is the second most prevalent neurodegenerative disor-der. Among its pathologies, progressive loss of dopaminergic (DA) neurons in the substantia nigra is characteristic and contributes to many of the most severe symptoms of PD. Recent advances in induced pluripotent stem cell (iPSC) tech-nology have made it possible to generate patient-derived DA neuronal cell culture and organoid models of PD. These models have contributed to understanding dis-ease mechanisms and the identification of novel targets and therapeutic candi-dates. Still needed are better ways to model the age-related aspects of PD, as well as a deeper understanding of the interactions among disease-modifying genes and between genetic and environmental contributions to the etiology and progression of PD. |
| Keywords: | dysfunction; dopaminergic-neurons; ipscs; alpha-synuclein; mitochondrial; impairment; lrrk2; gaucher-disease; glucocerebrosidase; triplication |
| Journal Title: | Trends in Neurosciences |
| Volume: | 45 |
| Issue: | 8 |
| ISSN: | 0166-2236 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2022-08-01 |
| Start Page: | 608 |
| End Page: | 620 |
| Language: | English |
| ACCESSION: | WOS:000831679100006 |
| DOI: | 10.1016/j.tins.2022.05.001 |
| PROVIDER: | wos |
| PUBMED: | 35667922 |
| Notes: | Review -- Source: Wos |
