Oxidative stress and cellular pathologies in Parkinson's disease Journal Article
| Authors: | Puspita, L.; Chung, S. Y.; Shim, J. W. |
| Article Title: | Oxidative stress and cellular pathologies in Parkinson's disease |
| Abstract: | Parkinson's disease (PD) is a chronic and progressive neurodegeneration of dopamine neurons in the substantia nigra. The reason for the death of these neurons is unclear; however, studies have demonstrated the potential involvement of mitochondria, endoplasmic reticulum, α-synuclein or dopamine levels in contributing to cellular oxidative stress as well as PD symptoms. Even though those papers had separately described the individual roles of each element leading to neurodegeneration, recent publications suggest that neurodegeneration is the product of various cellular interactions. This review discusses the role of oxidative stress in mediating separate pathological events that together, ultimately result in cell death in PD. Understanding the multi-faceted relationships between these events, with oxidative stress as a common denominator underlying these processes, is needed for developing better therapeutic strategies. © 2017 The Author(s). |
| Keywords: | carrier protein; disease course; review; nonhuman; cell death; protein binding; calcium; endoplasmic reticulum; cell damage; iron; reactive oxygen species; reactive oxygen metabolite; oxidative stress; protein folding; parkinson disease; mitochondria; mitochondrion; oxidation; dopamine; dopaminergic nerve cell; unfolded protein response; alpha-synuclein; dopamine neurons; parkinson's disease; substantia nigra; human; priority journal; alpha synuclein |
| Journal Title: | Molecular Brain |
| Volume: | 10 |
| ISSN: | 1756-6606 |
| Publisher: | BioMed Central Ltd. |
| Date Published: | 2017-11-28 |
| Start Page: | 53 |
| Language: | English |
| DOI: | 10.1186/s13041-017-0340-9 |
| PROVIDER: | scopus |
| PMCID: | PMC5706368 |
| PUBMED: | 29183391 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 2 January 2018 -- Source: Scopus |
