Feline cystic thymoma: A clinicopathologic, immunohistologic, and electron microscopic study of 14 cases Journal Article
| Authors: | Patnaik, A. K.; Lieberman, P. H.; Erlandson, R. A.; Antonescu, C. |
| Article Title: | Feline cystic thymoma: A clinicopathologic, immunohistologic, and electron microscopic study of 14 cases |
| Abstract: | Cystic thymoma was diagnosed in 14 cats in a period of 6 years. The most common clinical sign was laboured breathing. The tumours were characterized by various-sized cystic spaces with central vessels. The epithelial cells varied from oval to spindle to polygonal cells enclosing cystic spaces or in pure epithelial cell components. The nuclei of the neoplastic cells had scattered chromatin and small nucleoli. The cytoplasm was pale eosinophilic. The concentration of mature lymphocytes varied from area to area with rare germinal centres. Immunohistochemically, the epithelial cells stained only with AE1/AE3. The central vessels were positive for vimentin, smooth muscle actin, and factor VIII antigen. Electron microscopy revealed that the cyst walls were lined by epithelial cells that were joined by desmosomes, and the walls were well separated from the cystic spaces by a well-defined basement membrane. The neoplastic epithelial cells contained scattered tonofilaments. Three of the cats had metastasis to the lymph nodes and lungs. Two novel cases of ectopic cystic thymoma have also been described. Results of this study reveal that cystic thymoma is uncommon in cats, and that the histomorphologic, immunohistochemical, and electron microscopic features are similar to those of cystic thymoma in humans. © 2002 ESFM and AAFP. Published by Elsevier Science Ltd. All rights reserved. |
| Keywords: | immunohistochemistry; controlled study; aged; retrospective studies; clinical feature; histopathology; review; case report; nonhuman; united states; lymph node metastasis; animal; electron microscopy; animals; microscopy, electron; animal tissue; basement membrane; pathology; retrospective study; information processing; dyspnea; animal disease; lung metastasis; germinal center; cat; cat disease; cat diseases; cats; tumor cell; epithelium cell; cytoplasm; new york city; cell nucleus; cell shape; lymphocytic infiltration; thymoma; tumor vascularization; morphometrics; thymus neoplasms; chromatin structure; blood clotting factor 8; vimentin; nucleolus; felidae; alpha actin; immunohistology; desmosome; records; breathing disorder; felis catus; male; female; thymus cyst; tonofilament |
| Journal Title: | Journal of Feline Medicine and Surgery |
| Volume: | 5 |
| Issue: | 1 |
| ISSN: | 1098-612X |
| Publisher: | W.B. Saunders Co. |
| Date Published: | 2003-02-01 |
| Start Page: | 27 |
| End Page: | 35 |
| Language: | English |
| DOI: | 10.1053/jfms.2002.0187 |
| PUBMED: | 12547620 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
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