Genomic medicine and neuroblastoma Journal Article


Authors: Oppenheimer, O.; Alaminos, M.; Gerald, W. L.
Article Title: Genomic medicine and neuroblastoma
Abstract: Neuroblastic tumors are a broad biological and clinical spectrum of neoplastic disease that has long captured the attention of clinicians and scientists alike. It is the most common solid extracranial tumor in children and accounts for 8-10% of all childhood tumors. Tumors are derived from neural crest cells and neural differentiation is common. Neuroblastoma is unique in that it presents with at least three distinct patterns of disease. Locoregional disease (Stage 1, 2, 3) does not metastasize to bone or bone marrow. Stage 4 is a systemic disease with widespread metastasis that responds to chemotherapy but many develop resistance. Stage 4s presents in infancy, is widespread and can spontaneously regress with no intervention, leaving a focus of fibrosis or calcification. Prognosis correlates with age, stage and tumor biological profile. The goal of this review is to provide an overview of the disease and highlight diagnostic, prognostic and therapeutic advances in neuroblastoma. Recommendations and resources for the evaluation and treatment of this disease are outlined.
Keywords: cancer surgery; genetics; mutation; disease course; histopathology; pathogenesis; review; cisplatin; doxorubicin; cancer combination chemotherapy; multimodality cancer therapy; solid tumor; cancer radiotherapy; cancer staging; cancer diagnosis; chromosome 1; cancer immunotherapy; metastasis; gene amplification; gene expression; granulocyte macrophage colony stimulating factor; tumor markers, biological; protein; cyclophosphamide; telomerase; childhood cancer; age; fibrosis; molecular marker; rna; cancer genetics; cancer regression; fluorescence in situ hybridization; dna; neuroblastoma; diagnosis; tyrosine kinase receptor; gene loss; genomics; neural crest; chromosome aberrations; genetic disorder; isotretinoin; cancer classification; molecular biology; hermes antigen; bone marrow transplantation; genetic techniques; radiodiagnosis; gene technology; tumor calcinosis; epipodophyllotoxin; neurotrophin; ploidy; humans; prognosis; human
Journal Title: Expert Review of Molecular Diagnostics
Volume: 3
Issue: 1
ISSN: 1473-7159
Publisher: Informa Healthcare  
Date Published: 2003-01-01
Start Page: 39
End Page: 54
Language: English
DOI: 10.1586/14737159.3.1.39
PUBMED: 12528363
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 25 September 2014 -- Source: Scopus
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  1. William L Gerald
    375 Gerald