Pattern formation: Old models out on a limb Journal Article
| Author: | Niswander, L. |
| Article Title: | Pattern formation: Old models out on a limb |
| Abstract: | The vertebrate limb is an excellent model for studying fundamental aspects of embryonic development. Cell proliferation, death and movement, and the assignment and interpretation of positional information, must be coordinated if an exquisitely patterned limb is to form. Recent results from gene targeting in mice and from experimental manipulation of the chick embryonic limb have significantly altered the way in which developmental biologists have conceptualized limb patterning. |
| Keywords: | signal transduction; protein expression; unclassified drug; review; nonhuman; cell proliferation; mouse; phenotype; animals; cell death; cell survival; gene targeting; models, biological; embryo; sonic hedgehog protein; animal model; protein; cell motion; embryo development; embryo pattern formation; genetic manipulation; animalia; vertebrata; limb; extremities; clinical research; gene control; bone morphogenetic protein 2; erinaceidae; vertebrate; transcription factor gli3; body patterning; model; mesenchyme; fibroblast growth factor; finger; limb development; information; chicken; limb bud; body position; ulna; embryo (anatomy); coordination; limb deformity; priority journal; gallus gallus; apical ectodermal ridge |
| Journal Title: | Nature Reviews Genetics |
| Volume: | 4 |
| Issue: | 2 |
| ISSN: | 1471-0056 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2003-02-01 |
| Start Page: | 133 |
| End Page: | 143 |
| Language: | English |
| DOI: | 10.1038/nrg1001 |
| PUBMED: | 12560810 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
