Astrocyte differentiation states and glioma formation Journal Article
| Authors: | Dai, C.; Holland, E. C. |
| Article Title: | Astrocyte differentiation states and glioma formation |
| Abstract: | Gliomas are the most common primary malignancy in human central nervous system. Many similarities in cell morphology and expression of markers exist between cancerous cells and normal undifferentiated progenitor cells. At the molecular level, many important gene products are causally implicated in both the glial differentiation process and glial neoplasm formation. These observations raise the question of to what degree cell differentiation state influences glioma formation. In this review, we discuss new insights into the parallels between glial differentiation and glioma formation as well as the potential application of differentiation-inducing therapy. Copyright © 2003 Jones and Bartlett Publishers, Inc. |
| Keywords: | signal transduction; review; nonhuman; glioma; mouse; animal; metabolism; animals; mice; cell cycle; cell structure; gene overexpression; tumor differentiation; animal model; astrocyte; gene product; neural stem cell; cell differentiation; pathology; protein tyrosine kinase; physiology; cell transformation, neoplastic; models, animal; gene expression regulation; biosynthesis; cell transformation; tumor cell; cell cycle arrest; neuroglia; oligodendroglioma; receptor protein-tyrosine kinases; cell marker; growth factor; astrocytoma; glia; gliomagenesis; humans; human; priority journal; differentiation-inducing therapy; glial differentiation; glioma genetics |
| Journal Title: | The Cancer Journal |
| Volume: | 9 |
| Issue: | 2 |
| ISSN: | 1528-9117 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2003-03-01 |
| Start Page: | 72 |
| End Page: | 81 |
| Language: | English |
| DOI: | 10.1097/00130404-200303000-00002 |
| PUBMED: | 12784872 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
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