Update on non-acquired immunodeficiency syndrome-defining malignancies Journal Article


Authors: Chiao, E. Y.; Krown, S. E.
Article Title: Update on non-acquired immunodeficiency syndrome-defining malignancies
Abstract: Purpose of review: Since the introduction of highly active antiretroviral therapy (HAART), the natural history of human immunodeficiency virus (HIV) infection has changed. Early in the acquired immunodeficiency syndrome (AIDS) epidemic, epidemiologic studies showed that HIV-infected patients were at higher risk for developing specific AIDS-defining malignancies. More recent studies linking HIV/AIDS databases to cancer registries have shown that HIV-infected patients are also at higher risk of developing non-AIDS-defining malignancies. We review the most recent data regarding clinical presentation, pathology, and treatment outcomes for these non-AIDS-defining malignancies. Recent findings: Recent large cohort studies linking HIV/AIDS databases to cancer registries have shown that HIV-infected patients are also at higher risk of developing non-AIDS-defining malignancies. Besides anal cancer and Hodgkin disease, the cohort studies have identified other malignancies that appear to occur at a higher rate in the HIV-infected population as compared with the general population. These malignancies include lung cancer, skin cancer, germ cell tumors, leiomyosarcomas, cancers of the head and neck, conjunctival cancer, multiple myeloma, and leukemias. Summary: As the epidemiology of non-AIDS-defining malignancies continues to evolve, it is unclear whether the appropriate treatments and outcomes for these or other malignancies are changed for HIV-infected patients treated with HAART. © 2003 Lippincott Williams & Wilkins.
Keywords: treatment outcome; leukemia; clinical feature; review; cancer risk; human immunodeficiency virus infection; neoplasms; multiple myeloma; skin cancer; cohort analysis; lung cancer; pathology; data base; hodgkin disease; head and neck cancer; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; antiretrovirus agent; highly active antiretroviral therapy; antiretroviral therapy, highly active; leiomyosarcoma; anus cancer; germ cell tumor; hiv-infection; conjunctiva tumor; cancer; humans; human; male; female; priority journal; conjunctival cancer; non-aids-defining malignancy
Journal Title: Current Opinion in Oncology
Volume: 15
Issue: 5
ISSN: 1040-8746
Publisher: Lippincott Williams & Wilkins  
Date Published: 2003-09-01
Start Page: 389
End Page: 397
Language: English
DOI: 10.1097/00001622-200309000-00008
PUBMED: 12960522
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 25 September 2014 -- Source: Scopus
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MSK Authors
  1. Elizabeth Yu Chiao
    7 Chiao
  2. Susan Krown
    141 Krown
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