The epidemiology of multidrug-resistant Acinetobacter baumannii: Does the community represent a reservoir? Journal Article
| Authors: | Zeana, C.; Larson, E.; Sahni, J.; Bayuga, S. J.; Wu, F.; Della-Latta, P. |
| Article Title: | The epidemiology of multidrug-resistant Acinetobacter baumannii: Does the community represent a reservoir? |
| Abstract: | OBJECTIVE: To explore the role of the community as a potential reservoir for Acinetobacter baumannii. DESIGN: Antimicrobial resistance patterns and genotypes of A. baumannii isolates from patients in two Manhattan hospitals were compared with those of A. baumannii isolates from the hands of community members. RESULTS: A total of 103 isolates from two hospitals (hospital A, 81; hospital B, 22) and 23 isolates from community residents were studied. Of the hospital isolates, 36.6% were multidrug resistant (hospital A, 68.2%; hospital B, 27.8%). In contrast, there were no multidrug-resistant isolates from the community (P < .005 between hospital and community). The prevalence of A. baumannii on the hands of community residents was 10.4% (23 of 222). By molecular typing, 42 strains of A. baumannii were identified. Of the isolates from hospital A and hospital B, 55.6% (45 of 81) and 68.2% (15 of 22), respectively, were indistinguishable or closely related. In contrast, most community (83.3%) isolates were unrelated (P = .001 between hospital and community). CONCLUSION: Acinetobacter isolates from the community, characterized by a large variety of unrelated strains (83.3%), were distinct from the hospital isolates, of which 58.3% were closely related. The absence of multidrug-resistant strains in the community compared with 36.6% prevalence among hospital isolates suggests that the reservoir for epidemic strains resides in the hospital environment itself. To our knowledge, this is the first study to examine the community as a potential reservoir for hospital strains of A. baumannii. |
| Keywords: | antibiotic agent; nonhuman; prevalence; genotype; bacterial strain; antibiotic resistance; molecular typing; new york city; bacterium isolate; hospital infection; antibiotic sensitivity; dna determination; tobramycin; dna, bacterial; multidrug resistance; cross infection; acinetobacter baumannii; epidemic; acinetobacter infections; electrophoresis, gel, pulsed-field; drug resistance, multiple; ceftriaxone; piperacillin plus tazobactam; cefepime; sultamicillin; ceftazidime; meropenem; imipenem; amikacin; community-acquired infections; hospitals, teaching; piperacillin; humans; male; female; article; disease reservoirs |
| Journal Title: | Infection Control and Hospital Epidemiology |
| Volume: | 24 |
| Issue: | 4 |
| ISSN: | 0899-823X |
| Publisher: | The Society for Healthcare Epidemiology of America |
| Date Published: | 2003-04-01 |
| Start Page: | 275 |
| End Page: | 279 |
| Language: | English |
| DOI: | 10.1086/502209 |
| PUBMED: | 12725357 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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