In vivo multiple-mouse imaging at 1.5 T Journal Article
| Authors: | Xu, S.; Gade, T. P. F.; Matei, C.; Zakian, K.; Alfieri, A. A.; Hu, X.; Holland, E. C.; Soghomonyan, S.; Tjuvajev, J.; Ballon, D.; Koutcher, J. A. |
| Article Title: | In vivo multiple-mouse imaging at 1.5 T |
| Abstract: | A multiple-mouse solenoidal MR coil was developed for in vivo imaging of up to 13 mice simultaneously to screen for tumors on a 1.5 T clinical scanner. For the coil to be effective as a screening tool, it should permit acquisition of MRIs in which orthotopic tumors with diameters >2 mm are detectable in a reasonable period of time (<1 hr magnet time) and their sizes accurately measured. Using a spin echo sequence, we demonstrated that this coil provides sufficient sensitivity for moderately high resolution images (156-176 μm in plane-resolution, 1.5 mm slice thickness). This spatial resolution permitted detection of primary brain tumors in transgenic/knockout mice and orthotopic xenografts. Brain tumor size as measured by MRI was correlated with size measured by histopathology (P < 0.001). Metastatic tumors in the mouse lung were also successfully imaged in a screening setting. The multiple mouse coil is simple in construction and may be implemented without any significant modification to the hardware or software on a clinical scanner. © 2003 Wiley-Liss, Inc. |
| Keywords: | controlled study; histopathology; nonhuman; nuclear magnetic resonance imaging; brain tumor; glioma; brain neoplasms; magnetic resonance imaging; mouse; animals; mice; mice, knockout; tumor volume; lung neoplasms; signal noise ratio; animal experiment; animal model; transgenic mouse; mice, transgenic; models, animal; lung tumor; xenograft; feasibility studies; image quality; equipment design; tumor; computer program; knockout mouse; carcinoma, lewis lung; male; article; multiple mouse mri coil |
| Journal Title: | Magnetic Resonance in Medicine |
| Volume: | 49 |
| Issue: | 3 |
| ISSN: | 0740-3194 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2003-03-01 |
| Start Page: | 551 |
| End Page: | 557 |
| Language: | English |
| DOI: | 10.1002/mrm.10397 |
| PUBMED: | 12594759 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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