Nemaline myopathy: A possible late complication of Hodgkin's disease therapy Journal Article
| Authors: | Portlock, C. S.; Boland, P.; Hays, A. P.; Antonescu, C. R.; Rosenblum, M. K. |
| Article Title: | Nemaline myopathy: A possible late complication of Hodgkin's disease therapy |
| Abstract: | Patients who have undergone "mantle" field irradiation for Hodgkin's disease may develop symptomatic muscle atrophy in the treatment portal. This complication has received only scant attention in the clinical literature and its pathologic substrate has not been elucidated. We report the finding of nemaline myopathy in the previously irradiated and atrophic trapezius muscle of such a patient. Biopsy of clinically uninvolved gracilis muscle outside of the radiation portal revealed normal histology and ultrastructure. We are unaware of previous reports documenting such a phenomenon, which suggests that nemaline myopathy may evolve as a radiation-related disorder. © 2003 Elsevier Inc. All rights reserved. |
| Keywords: | adult; human tissue; treatment outcome; clinical feature; histopathology; case report; cancer radiotherapy; neoplasm staging; radiotherapy; biopsy; hodgkin disease; muscle weakness; radiation therapy; muscle biopsy; muscle, skeletal; muscle atrophy; cell ultrastructure; trapezius muscle; hodgkin's disease; humans; human; male; article; gracilis muscle; nemaline myopathy; muscular atrophy; myofibrils; myopathies, nemaline |
| Journal Title: | Human Pathology |
| Volume: | 34 |
| Issue: | 8 |
| ISSN: | 0046-8177 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2003-08-01 |
| Start Page: | 816 |
| End Page: | 818 |
| Language: | English |
| DOI: | 10.1016/s0046-8177(03)00242-9 |
| PUBMED: | 14506646 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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