Differential sensitivities of mouse strains to morphine and [Dmt1]DALDA analgesia Journal Article
| Authors: | Neilan, C. L.; King, M. A.; Rossi, G.; Ansonoff, M.; Pintar, J. E.; Schiller, P. W.; Pasternak, G. W. |
| Article Title: | Differential sensitivities of mouse strains to morphine and [Dmt1]DALDA analgesia |
| Abstract: | [Dmt1]DALDA (H-Dmt-D-Arg-Phe-Lys-NH2), is a highly potent and selective μ-opioid agonist. Nevertheless, systemic [Dmt1]DALDA retained its analgesic actions in MOR-1 knockout animals and CXBK mice despite the inactivity of morphine in these mice. [Dmt1]DALDA was 6-fold less potent in C57BL/6J mice than in CD-1 mice, whereas morphine potency did not differ between the two strains. Thus, [Dmt1]DALDA is a highly selective μ-opioid analgesic with significant pharmacological differences with the prototypic μ-opioid morphine. © 2003 Elsevier Science B.V. All rights reserved. |
| Keywords: | nonhuman; mouse; animals; mice; mice, knockout; animal experiment; drug potency; dose-response relationship, drug; drug selectivity; strain difference; mice, inbred balb c; mice, inbred c57bl; species specificity; mouse strain; morphine; analgesics, opioid; pain measurement; oligopeptides; drug sensitivity; analgesia; receptors, opioid, mu; knockout mouse; knockout; analgesic activity; mor-1; strain; male; priority journal; article; opioid peptide; μ-opioid receptor; tyrosyl dextro arginylphenylalanyllysinamide |
| Journal Title: | Brain Research |
| Volume: | 974 |
| Issue: | 1-2 |
| ISSN: | 0006-8993 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2003-06-06 |
| Start Page: | 254 |
| End Page: | 257 |
| Language: | English |
| DOI: | 10.1016/s0006-8993(03)02590-3 |
| PUBMED: | 12742645 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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