Methadone analgesia in morphine-insensitive CXBK mice Journal Article
| Authors: | Chang, A.; Emmel, D. W.; Rossi, G. C.; Pasternak, G. W. |
| Article Title: | Methadone analgesia in morphine-insensitive CXBK mice |
| Abstract: | Methadone, a potent opioid analgesic, has long been considered a μ-opioid, based upon the similarities between its actions and those of morphine. This classification is supported by the sensitivity of methadone analgesia to the highly μ-opioid receptor-selective antagonist β-funaltrexamine. Yet, CXBK mice respond normally to methadone despite their insensitivity to systemic morphine, distinguishing between the receptor mechanisms of the two drugs. β-Funaltrexamine antagonizes methadone analgesia in CXBK mice, implying that the opioid is still acting through a μ-opioid receptor. These results reveal distinct analgesic mechanisms for morphine and methadone and provide further support for multiple subtypes of μ-opioid receptors. |
| Keywords: | controlled study; nonhuman; mouse; animals; mice; animal experiment; animal model; drug resistance; methadone; morphine; analgesics, opioid; drug sensitivity; analgesia; mu opiate receptor; naloxone; opiate receptor; beta funaltrexamine; analgesic activity; receptor subtype; opiate antagonist; strain; subcutaneous drug administration; male; priority journal; article; μ-opioid receptor |
| Journal Title: | European Journal of Pharmacology |
| Volume: | 351 |
| Issue: | 2 |
| ISSN: | 0014-2999 |
| Publisher: | Elsevier B.V. |
| Date Published: | 1998-06-19 |
| Start Page: | 189 |
| End Page: | 191 |
| Language: | English |
| DOI: | 10.1016/s0014-2999(98)00366-5 |
| PUBMED: | 9687002 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 12 December 2016 -- Source: Scopus |
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