Abl family nonreceptor tyrosine kinases modulate short-term synaptic plasticity Journal Article
| Authors: | Moresco, E. M. Y.; Scheetz, A. J.; Bornmann, W. G.; Koleske, A. J.; Fitzsimonds, R. M. |
| Article Title: | Abl family nonreceptor tyrosine kinases modulate short-term synaptic plasticity |
| Abstract: | Abl family nonreceptor tyrosine kinases regulate cell morphogenesis through functional interactions with the actin cytoskeleton. The vertebrate Abl family kinases, Abl and Arg, are expressed in the adult mouse brain, where they may regulate actin cytoskeletal dynamics in mature neurons. Using immunoelectron microscopy, we have localized Abl and Arg to the pre- and postsynaptic compartments of synapses in the mouse hippocampal area CA1. Paired-pulse facilitation (PPF) was significantly reduced at the Schaffer collateral-CA1 (SC-CA1) excitatory synapses in hippocampal slices from abl-/- and arg-/- mice as compared with wild-type mice. Furthermore, treatment of wild-type slices with the specific Abl family kinase inhibitor STI571 also reduced PPF. Basal synaptic transmission, posttetanic potentiation (PTP), long-term potentiation (LTP), and long-term depression (LTD) were similar to wild-type controls in abl-/- and arg-/- slices and in STI571treated wild-type slices. These results indicate that an important function of Abl and Arg is to modulate synaptic efficacy via a presynaptic mechanism during repetitive activation. |
| Keywords: | controlled study; unclassified drug; nonhuman; protein localization; mouse; animals; mice; actin; animal tissue; imatinib; protein protein interaction; mice, mutant strains; morphogenesis; abelson kinase; protein tyrosine kinase; pyrimidines; enzyme inhibitors; probability; nerve cell plasticity; protein-tyrosine kinases; piperazines; organ culture techniques; protein family; cytoskeleton; facilitation; neuronal plasticity; synapses; hippocampus; presynaptic nerve; synaptic transmission; long-term potentiation; proto-oncogene proteins c-abl; central nervous system depression; microscopy, immunoelectron; priority journal; article; protein arg; long-term depression (physiology) |
| Journal Title: | Journal of Neurophysiology |
| Volume: | 89 |
| Issue: | 3 |
| ISSN: | 0022-3077 |
| Publisher: | American Physiological Society |
| Date Published: | 2003-03-01 |
| Start Page: | 1678 |
| End Page: | 1687 |
| Language: | English |
| DOI: | 10.1152/jn.00892.2002 |
| PUBMED: | 12626632 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
