The synergistic analgesic interactions between hydrocodone and ibuprofen Journal Article

  


Authors: Kolesnikov, Y. A.; Wilson, R. S.; Pasternak, G. W.
Article Title: The synergistic analgesic interactions between hydrocodone and ibuprofen
Abstract: The practice of combining opioids with nonsteroidal antiinflammatory drugs is widespread in the clinical management of acute and chronic pain. Using the mouse radiant heat tail-flick nociception model, we observed potent analgesia with hydrocodone. In contrast, ibuprofen as a single drug was inactive in this model of moderate to severe pain, perhaps reflecting its limited analgesic potential. Despite the inactivity of ibuprofen alone in this model, the inclusion of ibuprofen with hydrocodone markedly enhanced the analgesic response. Dose-response studies revealed an 50% effective dose for hydrocodone alone in mice of 11 mg/kg, SC. Inclusion of a fixed ibuprofen dose with the various hydrocodone doses shifted the 50% effective dose value almost seven-fold to the left to 1.6 mg/kg, SC, despite the lack of effect of ibuprofen alone in this model. Using a fixed hydrocodone:ibuprofen ratio (1:40) also revealed a marked four-fold shift to 2.6 mg/kg, SC. These findings suggest a synergistic interaction between ibuprofen and hydrocodone in a noninflammatory pain model.
Keywords: controlled study; drug activity; dose response; drug efficacy; drug potentiation; nonhuman; animals; mice; pain; animal experiment; animal model; drug potency; dose-response relationship, drug; drug synergism; ibuprofen; anti-inflammatory agents, non-steroidal; analgesics, opioid; pain measurement; analgesia; nociception; tail flick test; analgesic agent; reaction time; hydrocodone; heat; male; priority journal; article
Journal Title: Anesthesia and Analgesia
Volume: 97
Issue: 6
ISSN: 0003-2999
Publisher: Lippincott Williams & Wilkins  
Date Published: 2003-12-01
Start Page: 1721
End Page: 1723
Language: English
PUBMED: 14633549
PROVIDER: scopus
DOI: 10.1213/01.ANE.0000087801.20395.97
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0344530588&partnerID=40&md5=14d24be5a5daacb8a79fd22039687de9
Notes: Export Date: 12 September 2014 -- Source: Scopus
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MSK Authors
  1. Roger S Wilson
    38 Wilson
  2. Yuri Alexei Kolesnikov
    34 Kolesnikov
  3. Gavril W Pasternak
    414 Pasternak
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