Selective potentiation of opioid analgesia by nonsteroidal anti-inflammatory drugs Journal Article
| Authors: | Zelcer, S.; Kolesnikov, Y.; Kovalyshyn, I.; Pasternak, D. A.; Pasternak, G. W. |
| Article Title: | Selective potentiation of opioid analgesia by nonsteroidal anti-inflammatory drugs |
| Abstract: | Opioids are often used in conjunction with nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of moderate to severe pain. In this study we have examined interactions between these two classes of drugs. NSAIDs are inactive in the radiant heat tail-flick test, an assay of moderate to severe pain in which opioids are effective. In this assay, ibuprofen potentiated the analgesic actions of hydrocodone and oxycodone, shifting their ED50 values by 2.5-fold and 4.6-fold despite its inactivity when given alone. These opioid/NSAID interactions were dependent upon both the opioid and the NSAID. Neither aspirin nor ketorolac influenced hydrocodone actions in this model and ibuprofen did not potentiate fentanyl or morphine analgesia. Together, these studies demonstrate potent interactions between selected combinations of opioids and NSAIDS and may help explain the clinical utility of combinations. However, the findings also illustrate differences between the drugs within each class. © 2005 Elsevier B.V. All rights reserved. |
| Keywords: | controlled study; dose response; nonhuman; mouse; animals; mice; pain; opiate; animal experiment; dose-response relationship, drug; mice, inbred icr; drug synergism; disease severity; drug mechanism; acetylsalicylic acid; ibuprofen; naproxen; nonsteroid antiinflammatory agent; anti-inflammatory agents, non-steroidal; drug dose; methadone; morphine; analgesics, opioid; pain measurement; opioid; ketorolac; analgesia; tail flick test; fentanyl; analgesic activity; levorphanol; oxycodone; hydrocodone; synergy; nonsteroidal anti-inflammatory drugs |
| Journal Title: | Brain Research |
| Volume: | 1040 |
| Issue: | 1-2 |
| ISSN: | 0006-8993 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2005-04-08 |
| Start Page: | 151 |
| End Page: | 156 |
| Language: | English |
| DOI: | 10.1016/j.brainres.2005.01.070 |
| PUBMED: | 15804436 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 22" - "Export Date: 24 October 2012" - "CODEN: BRREA" - "Source: Scopus" |
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2Zelcer -
34
Kolesnikov -
414Pasternak -
12
Kovalyshyn
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