Histopathologic type: An independent prognostic factor in primary soft tissue sarcoma of the extremity? Journal Article
| Authors: | Koea, J. B.; Leung, D.; Lewis, J. J.; Brennan, M. F. |
| Article Title: | Histopathologic type: An independent prognostic factor in primary soft tissue sarcoma of the extremity? |
| Abstract: | Background: We attempted to define the effect of tumor histotype on local recurrence, distant metastasis, and disease-specific survival in patients with surgically treated primary extremity sarcoma. Methods: A total of 951 patients with primary, localized soft tissue extremity sarcoma were followed up prospectively. Patient- and tumor-related variables, including histopathologic type, were used to identify independent prognostic factors for the study end points of local recurrence, distant recurrence, and disease-specific survival. Results: There were 137 local recurrences, and significant adverse prognostic factors for local recurrence were patient age >50 years, microscopically positive margins, and malignant peripheral nerve tumor. Adverse prognostic factors for distant recurrence (200 patients) were tumor size >5 cm, tumors beneath the investing fascia, high tumor grade, and leiomyosarcoma. Of the 199 patients who died of disease-related causes, patient age >50 years, tumors beneath the investing fascia, high tumor grade, microscopically positive margin, tumor size >5 cm, leiomyosarcoma, and malignant peripheral nerve tumor were adverse prognostic factors. Conclusions: These data suggest that differences in biological behavior may exist between sarcoma histotypes and deserve further study. © 2003 The Society of Surgical Oncology, Inc. |
| Keywords: | adult; controlled study; human tissue; disease-free survival; middle aged; cancer surgery; surgical technique; major clinical study; histopathology; mortality; cancer localization; cancer recurrence; disease free survival; follow up; cancer grading; prospective study; prospective studies; metastasis; neoplasm recurrence, local; tumor volume; pathology; sarcoma; cause of death; fibrosarcoma; tumor recurrence; prognostic factors; limb tumor; soft tissue sarcoma; malignant neoplastic disease; multivariate analysis; age distribution; leiomyosarcoma; peripheral nerve tumor; soft tissue neoplasms; soft tissue tumor; peripheral nervous system neoplasms; liposarcoma; fascia; humans; prognosis; human; male; female; article |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 10 |
| Issue: | 4 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2003-05-01 |
| Start Page: | 432 |
| End Page: | 440 |
| Language: | English |
| DOI: | 10.1245/aso.2003.05.014 |
| PUBMED: | 12734093 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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