Primary African HIV clade A and D isolates: Effective cross-clade neutralization with a quadruple combination of human monoclonal antibodies raised against clade B Journal Article
| Authors: | Kitabwalla, M.; Ferrantelli, F.; Wang, T.; Chalmers, A.; Katinger, H.; Stiegler, G.; Cavacini, L. A.; Chou, T. C.; Ruprecht, R. M. |
| Article Title: | Primary African HIV clade A and D isolates: Effective cross-clade neutralization with a quadruple combination of human monoclonal antibodies raised against clade B |
| Abstract: | We investigated the ability of several human neutralizing monoclonal antibodies (nmAbs), originally raised against human immunodeficiency virus (HIV) clade B isolates, to neutralize primary clade A and D isolates as single agents and in combinations. All four primary HIV clade A isolates and five primary HIV clade D isolates tested were neutralized >99% by the quadruple combination of nmAbs IgG1b12, 2G12, 2F5, and 4E10. These mAbs recognize conserved epitopes on HIV-1 envelope (Env), resulting in strong cross-clade neutralization. Previously, we showed synergistic neutralization of primary HIV-1 clade C isolates in vitro by the same nMAb combination. We and others also showed neutralization of primary HIV clade B strains. Together, our data show that the quadruple combination of mAbs effectively neutralized primary HIV clade A, B, C, and D isolates. |
| Keywords: | controlled study; unclassified drug; human cell; drug efficacy; nonhuman; drug targeting; human immunodeficiency virus infection; in vitro study; monoclonal antibody; antibodies, monoclonal; antigen recognition; human immunodeficiency virus; virus strain; hiv infections; hiv-1; virus isolation; africa; neutralizing antibody; virus neutralization; hiv antibodies; neutralization tests; cross reactions; virus envelope; humans; human; priority journal; article; monoclonal antibody 2f5; monoclonal antibody 2g12; monoclonal antibody 4e10; monoclonal antibogy igg1b12 |
| Journal Title: | AIDS Research and Human Retroviruses |
| Volume: | 19 |
| Issue: | 2 |
| ISSN: | 0889-2229 |
| Publisher: | Mary Ann Liebert, Inc |
| Date Published: | 2003-02-01 |
| Start Page: | 125 |
| End Page: | 131 |
| Language: | English |
| DOI: | 10.1089/088922203762688630 |
| PUBMED: | 12639248 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
