Potent cross-group neutralization of primary human immunodeficiency virus isolates with monoclonal antibodies - Implications for acquired immunodeficiency syndrome vaccine Journal Article
| Authors: | Ferrantelli, F.; Kitabwalla, M.; Rasmussen, R. A.; Cao, C.; Chou, T. C.; Katinger, H.; Stiegler, G.; Cavacini, L. A.; Bai, Y.; Cotropia, J.; Ugen, K. E.; Ruprecht, R. M. |
| Article Title: | Potent cross-group neutralization of primary human immunodeficiency virus isolates with monoclonal antibodies - Implications for acquired immunodeficiency syndrome vaccine |
| Abstract: | Human immunodeficiency virus type 1 (HIV-1) is phylogenetically classified into groups and clades (or subtypes). Human neutralizing monoclonal antibodies (nMAbs), originally isolated from individuals infected with HIV-1 group M-clade B, neutralized not only primary HIV-1 clade B isolates in vitro but also primary isolates of other group M clades (A, C, D, E, and F). This corrected the previously held notion that primary HIV-1 isolates are resistant to neutralizing antibodies. Here we show that anti-HIV-1 group M-clade B nMAbs potently neutralized primary isolates of the phylogenetically distant HIV-1 group O. We and others have previously shown that passive immunization with human nMAbs protected adult or neonatal primates against infection with simian-human immunodeficiency virus strains encoding HIV-1 group M-clade B envelope genes. The in vitro cross-group neutralization shown here underscores the broad potential of these nMAbs against divergent virus variants and the relevance of their epitopes in the design of acquired immunodeficiency syndrome vaccines. |
| Keywords: | controlled study; unclassified drug; human cell; nonhuman; drug potency; in vitro study; drug design; monoclonal antibody; antibodies, monoclonal; epitope; human immunodeficiency virus; human immunodeficiency virus 1; hiv-1; phylogeny; virus isolation; cladistics; neutralizing antibody; virus neutralization; passive immunization; variation (genetics); human immunodeficiency virus vaccine; hiv antibodies; neutralization tests; aids vaccines; cross reactions; humans; human; priority journal; article; human immunodeficiency virus antibody; monoclonal antibody 2f5; monoclonal antibody 2g12; monoclonal antibody 4e10; monoclonal antibody b12; monoclonal antibody cl3; monoclonal antibody f105; monoclonal antibody f424; virus classification |
| Journal Title: | Journal of Infectious Diseases |
| Volume: | 189 |
| Issue: | 1 |
| ISSN: | 0022-1899 |
| Publisher: | Oxford University Press |
| Date Published: | 2004-01-01 |
| Start Page: | 71 |
| End Page: | 74 |
| Language: | English |
| DOI: | 10.1086/380102 |
| PROVIDER: | scopus |
| PUBMED: | 14702155 |
| DOI/URL: | |
| Notes: | J. Infect. Dis. -- Cited By (since 1996):38 -- Export Date: 16 June 2014 -- CODEN: JIDIA -- Source: Scopus |
