Immunization of hematopoietic stem cell transplant recipients against vaccine-preventable diseases Journal Article
| Authors: | Small, T. N.; Cowan, M. J. |
| Article Title: | Immunization of hematopoietic stem cell transplant recipients against vaccine-preventable diseases |
| Abstract: | Worldwide, over 40,000 hematopoietic cell transplants (HCT) are carried out each year, with the majority of patients surviving long term. Owing to their new immune systems, these patients are susceptible to a variety of preventable infectious diseases. The 2009 influenza pandemic, the increase in pertussis and antibiotic-resistant pneumococcus, as well as recent outbreaks of measles and mumps in immunocompetent individuals further highlight the need for effective revaccination of HCT recipients. Post-transplant vaccine guidelines, including those published in 2009, recommend immunization of all patient groups at fixed times post-HCT. Although early vaccination to protect against vaccine-preventable diseases is desirable, there are still limited data on whether this approach is efficacious in patient groups whose immune recovery differs from recipients of an unmodified HLA-matched sibling transplant. In the absence of such data, prospective trials are needed to better define the optimal timing for immunizing recipients of alternative donors. Ideally, such trials should be designed to identify biological markers that will predict an optimal and durable vaccine response. © 2011 Expert Reviews Ltd. |
| Keywords: | treatment response; fludarabine; review; hepatitis b; nonhuman; treatment duration; rituximab; drug megadose; low drug dose; aciclovir; cyclophosphamide; pneumococcus vaccine; allogenic bone marrow transplantation; herpes zoster; practice guideline; hematopoietic stem cell transplantation; acute leukemia; hla matching; immunogenicity; cd4+ t lymphocyte; graft versus host reaction; single drug dose; t cell depletion; immunosuppressive treatment; hepatitis b vaccine; pneumococcal infection; graft recipient; chickenpox; immunocompetence; cd45ra antigen; diphtheria tetanus vaccine; pertussis; immunocompromised patient; diphtheria; immunization; tetanus; varicella zoster vaccine; measles mumps rubella vaccine; immune reconstitution; hematopoietic cell transplantation; unrelated donor; pertussis toxin; valaciclovir; hla-matched sibling; t-cell depletion; haemophilus influenzae type b vaccine plus hepatitis b vaccine; haemophilus infection; hemagglutination; measles; mumps; rubella; seroconversion |
| Journal Title: | Expert Review of Clinical Immunology |
| Volume: | 7 |
| Issue: | 2 |
| ISSN: | 1744-666X |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2011-03-01 |
| Start Page: | 193 |
| End Page: | 203 |
| Language: | English |
| DOI: | 10.1586/eci.10.103 |
| PROVIDER: | scopus |
| PUBMED: | 21426257 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "Source: Scopus" |
