Current status and future directions in breast cancer therapy Journal Article
| Author: | Hudis, C. A. |
| Article Title: | Current status and future directions in breast cancer therapy |
| Abstract: | With the majority of breast cancers in the United States diagnosed at an early stage, treatment is focused on cure and the prevention of relapse due to micrometastatic disease. Because systemic adjuvant therapy effectively prevents or delays some relapses and deaths in early-stage disease, this treatment approach has become widespread throughout most of the Western world. The mainstay of care for patients with breast cancer has become local therapy, consisting of surgery, radiation treatment, or both, along with adjuvant systemic therapy, which can include tamoxifen, combination chemotherapy, hormonal therapy, or a combination of these treatments. Despite this wide range of effective therapeutic interventions, therapy for metastatic disease remains focused on improving overall survival and maintaining quality of life. Future efforts are focused on improving current treatment options by optimizing dose regimens, developing effective chemotherapy combinations, using novel approaches such as HER2/neu antibody-directed therapies, and providing palliative care in the latter stages of disease. |
| Keywords: | cancer survival; controlled study; treatment outcome; cancer recurrence; doxorubicin; fluorouracil; cancer combination chemotherapy; systemic therapy; united states; drug targeting; capecitabine; gemcitabine; paclitaxel; adjuvant therapy; cancer adjuvant therapy; cancer patient; cancer radiotherapy; chemotherapy, adjuvant; combined modality therapy; chemotherapy; methotrexate; cancer staging; lymph node metastasis; antineoplastic agent; lymph node dissection; cancer palliative therapy; medical decision making; quality of life; breast cancer; mastectomy; epidermal growth factor receptor 2; combination chemotherapy; cyclophosphamide; vincristine; breast neoplasms; cancer mortality; vinblastine; docetaxel; axillary lymph node; patient care; prednisolone; randomized controlled trials; mitoxantrone; daunorubicin; neoplasm metastasis; tamoxifen; nausea and vomiting; epirubicin; hormonal therapy; metastasis potential; trastuzumab; navelbine; mitomycin; anthracycline; alopecia; pemetrexed; breast surgery; antineoplastic protocols; raltitrexed; practice guidelines; hormone derivative; humans; human; female; article |
| Journal Title: | Clinical Breast Cancer |
| Volume: | 4 |
| Issue: | Suppl.2 |
| ISSN: | 1526-8209 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2003-11-01 |
| Start Page: | S70 |
| End Page: | S75 |
| Language: | English |
| PUBMED: | 14667277 |
| PROVIDER: | scopus |
| DOI: | 10.3816/CBC.2003.s.018 |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
