Design of antineoplastic agents based on the '2-phenylnaphthalene-type' structural pattern - Synthesis and biological activity studies of 11H-indolo[3.2-c]quinoline derivatives Journal Article
| Authors: | He, L.; Chang, H. X.; Chou, T. C.; Savaraj, N.; Cheng, C. C. |
| Article Title: | Design of antineoplastic agents based on the '2-phenylnaphthalene-type' structural pattern - Synthesis and biological activity studies of 11H-indolo[3.2-c]quinoline derivatives |
| Abstract: | Designed as a new group of planar molecule containing the proposed 2-phenylnaphthalene-type structure, a number of 11H-indolo[3.2-c]quinoline derivatives were synthesized and evaluated biologically. Several compounds were found to possess cytotoxic activity against the growth of human promyelocytic leukemia cells (HL-60), against the small cell lung cancer (SCLC), and showed good response in the National Cancer Institute preclinical antitumor drug discovery 60-cell line panel. © 2002 Éditions scientifiques et médicales Elsevier SAS. All rights reserved. |
| Keywords: | controlled study; unclassified drug; human cell; clinical trial; antineoplastic agents; antineoplastic agent; controlled clinical trial; drug structure; drug screening; drug screening assays, antitumor; cell line, tumor; drug design; structure-activity relationship; cancer center; lung small cell cancer; leukemia cell; promyelocytic leukemia; molecular structure; drug cytotoxicity; indoles; models, chemical; drug formulation; molecule; quinolines; quinoline derivative; naphthalene derivative; antitumor activity; naphthalenes; hl-60 cells; humans; human; article; 11h-indolo[3.2-c]quinoline derivatives; 2-phenylnaphthalene-type; 2 phenylnaphthalene |
| Journal Title: | European Journal of Medicinal Chemistry |
| Volume: | 38 |
| Issue: | 1 |
| ISSN: | 0223-5234 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2003-01-01 |
| Start Page: | 101 |
| End Page: | 107 |
| Language: | English |
| DOI: | 10.1016/s0223-5234(02)01420-4 |
| PUBMED: | 12593920 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
