Design of antineoplastic agents on the basis of the "2-phenylnaphthalene-type" structural pattern. I. Synthesis of substituted 3-phenylquinazolones, benzoxazolo[2,3-b]quinazolones and benzothiazolo[2,3-b]quinazolones Journal Article
| Authors: | Cheng, C. C.; Liu, D. F.; Chou, T. C. |
| Article Title: | Design of antineoplastic agents on the basis of the "2-phenylnaphthalene-type" structural pattern. I. Synthesis of substituted 3-phenylquinazolones, benzoxazolo[2,3-b]quinazolones and benzothiazolo[2,3-b]quinazolones |
| Abstract: | A number of substituted 3-phenylquinazolin-4-ones, 12H-benzoxazolo-[2, 3-b]quinazolin-12-ones and 12H-benzothiazolo[2, 3-b]quinazolin-12-ones were designed and synthesized on the basis of a "2-phenylnaphthalene-type" structural pattern hypothesis. The postulated pattern, which was uncovered among a substantial number of compounds of both natural and synthetic origins, was noted to be associated with compounds possessing a variety of biological properties which include the antineoplastic activity. Several compounds designed for the present study were found to exhibit potent cytotoxicity against the growth of human promyelocytic leukemia (HL-60) cells. © 1993. |
| Journal Title: | Heterocycles |
| Volume: | 35 |
| Issue: | 2 |
| ISSN: | 0385-5414 |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Date Published: | 1993-01-01 |
| Start Page: | 775 |
| End Page: | 789 |
| Language: | English |
| DOI: | 10.3987/com-92-s(t)51 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
