| Abstract: |
A number of isoindolo[l ,2- b]quinazolines and some benzo[4,5]isoquinolino[l,2- b]quinazolines as structural modification analogues of the antitumor compound batracylin were synthesized and evaluated against HL-60 cell growth and in topoisomerase II-mediated DNA cleavage assays. Of the compounds studied, 10,12-dihydro-7,8-methy lenedioxyisoindolo[ 1,2- b] quinazolin-12(10 H)-one 1d, 2-amino-10,12-dihydroisoindolo[l ,2- b]quinazolin- 12(10 H)-one 1p, and 2-amino-7,8-methylenedioxy-10,12-dihydroisoindolo[l ,2- b]quinazolin-12(10 H)-one 1ab exhibited good inhibitory activities against HL-60 cell lines as well as induction of topo II-mediated DNA cleavage activities. © 1993, Plenum Publishing Corporation. All rights reserved. |
| Keywords: |
human cell; drug activity; antineoplastic agents; antineoplastic activity; cytotoxicity; tumor cells, cultured; drug synthesis; structure activity relation; structure-activity relationship; cell culture; dna, neoplasm; colon carcinoma; quinazolines; hydrolysis; dna topoisomerases, type ii; dna topoisomerase; isoindole derivative; human; article; support, non-u.s. gov't; quinazolinone derivative; colon adenocarcinoma 38; isoindolo[l,2- b]quinazolines; structure–activity relationship; batracylin
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