| Abstract: |
ETS proteins (such as PU.1, Fli-1 and ETS-1) have been shown to play important roles in normal and abnormal hematopoiesis. We examined the expression of the ELF subfamily of ETS genes (ELF-1, MEF and NERF) in acute myeloid leukemia (AML) cells using Northern blot analysis. ELF-1 and MEF were expressed in all samples, whereas NERF was not. The relative expression (RE) of MEF, but not ELF-1, was significantly lower (P<0.0001) in AML with t(8;21) and t(15;17) compared with AML with normal karyotype. The pattern of MEF expression was not uniform among cells with CD34(+)/CD33(+). It is suggested that the low RE of MEF might be part of a gene expression profile characterizing AML with a good prognosis. © 2002 Elsevier Science Ltd. All rights reserved. |
| Keywords: |
adult; clinical article; controlled study; aged; middle aged; unclassified drug; acute granulocytic leukemia; human cell; dna-binding proteins; cd34 antigen; gene expression; gene expression profiling; tumor markers, biological; transcription factor; chromosomes, human, pair 8; transcription factors; rna, messenger; leukemia, myeloid; hematopoietic stem cells; translocation, genetic; karyotype; karyotyping; rna, neoplasm; acute disease; cd33 antigen; multigene family; gene expression regulation, leukemic; northern blotting; chromosomes, human, pair 21; chromosomes, human, pair 17; chromosomes, human, pair 15; aml; mef; transcription factor elf 1; humans; prognosis; human; male; female; priority journal; article; ets genes; myocyte enhancer factor; transcription factor nerf
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