Erythropoietin and the erythropoietin receptor are expressed by papillary thyroid carcinoma from children and adolescents. Expression of erythropoietin receptor might be a favorable prognostic indicator Journal Article
| Authors: | Eccles, T. G.; Patel, A.; Verma, A.; Nicholson, D.; Lukes, Y.; Tuttle, R. M.; Francis, G. L. |
| Article Title: | Erythropoietin and the erythropoietin receptor are expressed by papillary thyroid carcinoma from children and adolescents. Expression of erythropoietin receptor might be a favorable prognostic indicator |
| Abstract: | Erythropoietin (EPO) and the EPO receptor (EPO-R) have been implicated in solid tumors of the brain, breast, kidney and female genital tract. Based on their expression by a variety of tumors, we hypothesized that EPO and/or EPO-R might be expressed by thyroid cancers. To test this, we determined EPO and EPO-R expression by immunohistochemistry in 17 papillary thyroid carcinomas (PTC) from children and adolescents. Only a minority of PTC (4/17, 24%) expressed EPO, and there were no significant differences between the PTC that did or did not express EPO. In contrast, EPO-R was detected in the majority of PTC (11/17, 65%). The average tumor size (1.5 ± 0.8 cm), MACIS score (3. 6 ± 0.2) and risk of recurrence (0/11) for the EPO-R(+) PTC were significantly less than those for PTC that failed to express EPO-R (average tumor size = 3.6 ± 2.4 cm, p = 0.021; average MACIS score = 4.3 ± 0.7, p = 0.004; recurrence = 3/6, p = 0.029). We conclude that the majority of PTC from children and adolescents express EPO-R, a finding associated with favorable prognostic indicators and a lower risk of recurrence. |
| Keywords: | immunohistochemistry; adolescent; adult; cancer survival; child; clinical article; controlled study; preschool child; protein expression; cancer recurrence; solid tumor; recurrence risk; erythropoietin; tumor volume; carcinoma, papillary; childhood cancer; radioactive iodine; reverse transcriptase polymerase chain reaction; rna, messenger; scoring system; thyroid neoplasms; thyroid papillary carcinoma; thyroid; radioisotope therapy; erythropoietin receptor; staining and labeling; receptors, erythropoietin; cancer; humans; prognosis; human; male; female; priority journal; article |
| Journal Title: | Annals of Clinical and Laboratory Science |
| Volume: | 33 |
| Issue: | 4 |
| ISSN: | 0091-7370 |
| Publisher: | Association of Clinical Scientists |
| Date Published: | 2003-01-01 |
| Start Page: | 411 |
| End Page: | 422 |
| Language: | English |
| PUBMED: | 14584755 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
