The MACIS score predicts the clinical course of papillary thyroid carcinoma in children and adolescents Journal Article
| Authors: | Powers, P. A.; Dinauer, C. A.; Tuttle, R. M.; Francis, G. L. |
| Article Title: | The MACIS score predicts the clinical course of papillary thyroid carcinoma in children and adolescents |
| Abstract: | MACIS (distant Metastasis, patient Age, Completeness of resection, local Invasion, and tumor Size) scores are employed to predict mortality for papillary thyroid carcinoma (PTC) in adults. However, this system has not been validated in children and adolescents. We hypothesized that MACIS scores would correlate with recurrent and persistent disease in children. Patients with PTC (n = 48) were divided into those with aggressive (invasive, metastasic, recurrent or persistent disease) or indolent (lacking these features) disease. Those with aggressive PTC (n = 11) had average MACIS score = 5.2 ± 1.3, compared to 3.7 ± 0.4 in patients with indolent disease (n = 37, p <0.0005). A cutoff score of 4.0 provides a PPV of 29% and NPV of 94% in predicting recurrence, and a PPV of 43% and NPV of 91% in predicting persistent disease. MACIS scores may be useful in predicting outcome in the pediatric population. © Freund Publishing House Ltd., London. |
| Keywords: | adolescent; adult; child; clinical article; controlled study; treatment outcome; child, preschool; cancer surgery; retrospective studies; clinical feature; disease course; cancer localization; validation process; research design; recurrent cancer; neoplasm staging; metastasis; cohort studies; neoplasm recurrence, local; carcinoma, papillary; prediction; childhood cancer; time factors; age; correlation analysis; disease progression; cancer size; scoring system; neoplasm invasiveness; thyroid carcinoma; thyroid neoplasms; papillary carcinoma; children; disease activity; humans; prognosis; human; male; female; article; macis |
| Journal Title: | Journal of Pediatric Endocrinology and Metabolism |
| Volume: | 17 |
| Issue: | 3 |
| ISSN: | 0334-018X |
| Publisher: | De Gruyter |
| Date Published: | 2004-03-01 |
| Start Page: | 339 |
| End Page: | 343 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 15112910 |
| DOI/URL: | |
| Notes: | J. Pediatr. Endocrinol. Metab. -- Cited By (since 1996):10 -- Export Date: 16 June 2014 -- CODEN: JPEMF C2 - 15112910 -- Source: Scopus |
