Fluid intake and the risk of tumor recurrence in patients with superficial bladder cancer Journal Article
| Authors: | Donat, S. M.; Bayuga, S.; Herr, H. W.; Berwick, M. |
| Article Title: | Fluid intake and the risk of tumor recurrence in patients with superficial bladder cancer |
| Abstract: | Purpose: High fluid intake has been associated with a decreased risk of bladder cancer development in men. We evaluated whether higher fluid intake can impact tumor recurrence rates in patients with superficial bladder cancer. Materials and Methods: We conducted a prospective single institution analysis of fluid intake in 267 consecutive patients with superficial bladder cancer undergoing routine bladder cancer surveillance between January 1998 and December 2001. Fluid intake questionnaires, urine cytology and physical examination were routinely performed at each surveillance cystoscopy. Cytological and histological recurrences were recorded. All patients had a minimum followup of 2 years. Results: No relationship between fluid intake and tumor recurrence was demonstrated. Average daily fluid intake was 2,654 ml daily, which was well within the highest protective level (more than 2,531 ml) previously reported. However, multivariate analysis failed to show a protective effect against recurrence at any level of fluid intake. Increasing age correlated with decreased fluid intake (Pearson's correlation coefficient -0.19, p = 0.0015), but did not increase the risk of recurrence (p = 0.59). Single fluid intake data correlated with the average of additional fluid intakes (median 5 per patient) in the same patient (Pearson's correlation coefficient, 0.45, p < 0.0001). Of the study population 123 patients (46%) experienced 1 or more tumor recurrences (range 0 to 11) within a median followup of 2.6 years. Conclusions: Our prospective study of fluid intake in patients with superficial bladder cancer at risk for recurrence did not find any association between daily fluid intake levels and tumor recurrence. |
| Keywords: | adult; cancer chemotherapy; controlled study; human tissue; aged; human cell; major clinical study; clinical trial; histopathology; cancer recurrence; cancer risk; follow up; follow-up studies; antineoplastic agent; neoplasm staging; prospective study; prospective studies; cancer prevention; controlled clinical trial; neoplasm recurrence, local; risk factors; recurrence; patient monitoring; bladder cancer; urinary bladder neoplasms; age; risk assessment; risk; questionnaire; correlation analysis; correlation coefficient; evaluation; cancer cytodiagnosis; cystectomy; urinary bladder; urine; multivariate analysis; bladder neoplasms; cystoscopy; cancer epidemiology; physical examination; carcinoma, transitional cell; fluid intake; prevention and control; urine cytology; protection; superficial cancer; drinking; humans; human; male; female; priority journal; article |
| Journal Title: | Journal of Urology |
| Volume: | 170 |
| Issue: | 5 |
| ISSN: | 0022-5347 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2003-11-01 |
| Start Page: | 1777 |
| End Page: | 1780 |
| Language: | English |
| DOI: | 10.1097/01.ju.0000091803.35049.da |
| PUBMED: | 14532774 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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