Results of a multicenter trial using the BTA test to monitor for and diagnose recurrent bladder cancer Journal Article
| Authors: | Sarosdy, M. F.; deVere White, R. W.; Soloway, M. S.; Sheinfeld, J.; Hudson, M. A.; Schellhammer, P. F.; Jarowenko, M. V.; Adams, G.; Blumenstein, B. A. |
| Article Title: | Results of a multicenter trial using the BTA test to monitor for and diagnose recurrent bladder cancer |
| Abstract: | Objectives: We compare the Bard BTA† † Bainbridge Diagnotic Sciences, C.R. Bard, Inc., Redmond, WA. (bladder tumor antigen) test to voided cytology studies in patients undergoing surveillance cystoscopy for recurrent bladder cancer. Materials and Methods: A prospective, blinded, multicenter trial was performed. Results: A total of 499 patients underwent 1,014 cystoscopic examinations and tumor was identified in 151. The bladder tumor antigen test was mode sensitive than cytology studies in detecting recurrent cancer (p less than 0.001), being positive in 61 cases versus 25 for cytology. The trial in healthy volunteers and nonurological patients estimates bladder tumor antigen test specificity to be 95.9 percent. Conclusions: The bladder tumor antigen test is a simple, rapid and inexpensive adjunct to cystoscopy, and the results are equivalent or superior to those of voided cytology as performed in this trial. © 1995 American Urological Association, Inc. |
| Keywords: | adult; controlled study; human tissue; aged; aged, 80 and over; unclassified drug; human cell; major clinical study; cancer recurrence; comparative study; neoplasm staging; diagnostic accuracy; sensitivity and specificity; prospective studies; bladder cancer; tumor antigen; antigens, neoplasm; antigen specificity; cancer cytodiagnosis; diagnostic value; antigen detection; predictive value of tests; urine; bladder neoplasms; cystoscopy; single-blind method; micturition; monitoring, physiologic; bladder tumor antigen; human; male; female; priority journal; article |
| Journal Title: | Journal of Urology |
| Volume: | 154 |
| Issue: | 2 |
| ISSN: | 0022-5347 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1995-08-01 |
| Start Page: | 379 |
| End Page: | 384 |
| Language: | English |
| DOI: | 10.1016/s0022-5347(01)67054-x |
| PUBMED: | 7609102 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
