Adult spermatic cord sarcomas: Management and results Journal Article
| Authors: | Coleman, J.; Brennan, M. F.; Alektiar, K.; Russo, P. |
| Article Title: | Adult spermatic cord sarcomas: Management and results |
| Abstract: | Background: We present a 20-year surgical experience with spermatic cord sarcoma, describe prognostic features, and evaluate the results of surgical and adjunctive treatments. Methods: Forty-seven patients were identified from an institutional database. Disease-free survival was calculated, and prognostic factors such as tumor grade, size, extent of operation, and adjuvant therapy were analyzed. Results: The median patient age was 58 years (range, 16-83 years), and the median follow-up was 51 months (range, .5-226 months). The most common tumor types included liposarcoma (51%), leiomyosarcoma (19%), embryonal rhabdomyosarcoma (13%), and malignant fibrous histiocytoma (11%). Twenty-nine (62%) patients had high-grade tumors, 21 (45%) were treated with adjuvant radiation, and 9 (19%) received chemotherapy. The overall 5- and 10-year disease-specific survival was 75% and 55%, respectively. No specific prognostic factors were identified for recurrence or disease-free survival. In 21 patients who underwent reoperative wide resection after a prior incomplete resection, a trend toward improved disease-free survival was noted (P < .059). Of these, six (29%) had residual viable sarcoma. We could not demonstrate a therapeutic effect of adjuvant radiation or chemotherapy. Conclusions: We demonstrated that aggressive surgical strategies, including reoperative wide resection, significantly decrease local recurrence and may improve disease free-survival in select patients with spermatic cord sarcoma. © 2003 The Society of Surgical Oncology, Inc. |
| Keywords: | adolescent; adult; cancer chemotherapy; cancer survival; clinical article; aged; aged, 80 and over; disease-free survival; middle aged; cancer surgery; doxorubicin; cancer radiotherapy; disease free survival; chemotherapy, adjuvant; cancer staging; follow up; cancer diagnosis; neoplasm staging; cancer grading; neoplasm recurrence, local; tumor volume; pathology; sarcoma; tumor recurrence; adjuvant chemotherapy; reoperation; brachytherapy; age distribution; leiomyosarcoma; malignant fibrous histiocytoma; factual database; databases, factual; embryonal rhabdomyosarcoma; liposarcoma; re-resection; paratesticular; genital neoplasms, male; male genital tract tumor; humans; prognosis; human; male; article; spermatic cord; spermatic cord sarcoma |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 10 |
| Issue: | 6 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2003-07-01 |
| Start Page: | 669 |
| End Page: | 675 |
| Language: | English |
| DOI: | 10.1245/aso.2003.11.014 |
| PUBMED: | 12839852 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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