Importance of wide re-resection in adult spermatic cord sarcomas: Report on oncologic outcomes at a single institution Journal Article
| Authors: | Murray, K. S.; Vertosick, E. A.; Spaliviero, M.; Mashni, J. W. Jr; Sjoberg, D. D.; Alektiar, K. M.; Herr, H. W.; Russo, P.; Coleman, J. A. |
| Article Title: | Importance of wide re-resection in adult spermatic cord sarcomas: Report on oncologic outcomes at a single institution |
| Abstract: | Background and Objectives: We evaluated the effect of re-resection with wide margins (undertaken because initial resection performed elsewhere was incomplete) on survival in patients with spermatic cord sarcoma (SCS). Methods: After excluding those with metastatic disease and those not undergoing surgical intervention, the records of 72 consecutive patients treated for SCS between 1981 and 2011 at Memorial Sloan Kettering Cancer Center were reviewed. Recurrence-free survival (RFS) and cancer-specific survival were calculated using the Kaplan-Meier method for comparing between the 48 patients who underwent wide re-resection (WRR) within 5 months of diagnosis and the 24 who did not. The relationship of age, tumor size, tumor histology, adjuvant radiation, and wide re-resection with recurrence and death was assessed by univariate Cox regression. Results: WRR significantly improved RFS (hazard ratio [HR] 0.16, 95%CI 0.07-0.37; P < 0.0001), despite the fact that patients receiving WRR had higher-grade disease. Tumor-positive margins upon WRR were strongly associated with both disease recurrence (HR 5.56; 95%CI 1.14-27.11, P = 0.034) and death from cancer (HR 6.16, 95%CI 1.25-30.29; P = 0.025). Conclusions: A WRR with negative margins is effective in the management of patients with SCS and leads to improved RFS. © 2018 Wiley Periodicals, Inc. |
| Keywords: | adult; cancer chemotherapy; cancer survival; aged; middle aged; cancer surgery; survival rate; retrospective studies; major clinical study; overall survival; clinical trial; mortality; salvage therapy; cancer patient; follow up; follow-up studies; tumor localization; neoplasm recurrence, local; tumor volume; pathology; retrospective study; histology; cancer mortality; sarcoma; cancer specific survival; tumor recurrence; recurrent disease; spindle cell; leiomyosarcoma; malignant fibrous histiocytoma; adjuvant radiotherapy; patient referral; embryonal rhabdomyosarcoma; liposarcoma; recurrence free survival; surgical margin; wide excision; re-resection; male genital tract tumor; humans; prognosis; human; male; female; priority journal; article; spermatic cord; spermatic cord sarcoma; myosarcoma; margins of excision; negative margins; wide re resection |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 117 |
| Issue: | 7 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2018-06-01 |
| Start Page: | 1464 |
| End Page: | 1468 |
| Language: | English |
| DOI: | 10.1002/jso.25016 |
| PUBMED: | 29473967 |
| PROVIDER: | scopus |
| PMCID: | PMC6028307 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 August 2018 -- Source: Scopus |
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