Dicer is essential for mouse development Journal Article
| Authors: | Bernstein, E.; Kim, S. Y.; Carmell, M. A.; Murchison, E. P.; Alcorn, H.; Li, M. Z.; Mills, A. A.; Elledge, S. J.; Anderson, K. V.; Hannon, G. J. |
| Article Title: | Dicer is essential for mouse development |
| Abstract: | To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1-null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1-null embryonic stem (ES) cells, this suggests a role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development. |
| Keywords: | nonhuman; animal cell; mouse; mammalia; animals; mice; mice, knockout; cell viability; gene; embryo; animal model; embryo development; gene function; rna interference; animalia; stem cell; rna; dead-box rna helicases; amino acid sequence; molecular sequence data; gene disruption; mammal; stem cells; gene silencing; rna helicases; lethality; endoribonucleases; priority journal; article; embryonic and fetal development; dicer 1 gene |
| Journal Title: | Nature Genetics |
| Volume: | 35 |
| Issue: | 3 |
| ISSN: | 1061-4036 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2003-11-01 |
| Start Page: | 215 |
| End Page: | 217 |
| Language: | English |
| DOI: | 10.1038/ng1253 |
| PUBMED: | 14528307 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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