SSX antigens as tumor vaccine targets in human sarcoma Journal Article

Authors: Ayyoub, M.; Brehm, M.; Metthez, G.; Talbot, S.; Dutoit, V.; Taub, R. N.; Keohan, M. L.; Gure, A. O.; Chen, Y. T.; Williamson, B.; Jungbluth, A. A.; Old, L. J.; Hesdorffer, C. S.; Valmori, D.
Article Title: SSX antigens as tumor vaccine targets in human sarcoma
Abstract: The efficacy of current standard therapies for the treatment of sarcoma remains limited. With the aim of identifying target antigens relevant to the development of vaccine-based immunotherapy of sarcoma, we have addressed the relevance of tumor-specific antigens encoded by genes belonging to the SSX family as vaccine targets in sarcoma tumors. Expression of SSX-1 to -5 was analyzed in a collection of sarcoma tumors of diverse histological subtypes and in sarcoma cell lines. We found expression of at least one SSX-encoded antigen in 42% of sarcoma tumors, including 5 of 7 different histological subtypes, and in 50% of sarcoma cell lines. SSX-1 was the most frequently expressed family member, followed by SSX-4, -2 and -5. Expression of SSX-3 was detected in only one sample. Importantly, most SSX positive samples co-expressed more than one family member. In addition, assessment of CD8+ T cell recognition of HLA-A2+ SSX-2+ sarcoma cells showed that the latter were efficiently recognized and lysed by SSX-2-specific CTLs. The results of this study indicate that SSX antigens are relevant targets for the development of vaccine-based immunotherapy of sarcoma and encourage the start of vaccination trials using SSX-derived immunogens in sarcoma patients.
Keywords: controlled study; unclassified drug; human cell; cd8 antigen; antigen expression; t lymphocyte; gastrointestinal stromal tumor; cancer immunotherapy; gene expression; cell line; tumor antigen; histology; sarcoma; fibrosarcoma; tumor antigens; epitope; leiomyosarcoma; malignant fibrous histiocytoma; synovial sarcoma; tumor vaccine; liposarcoma; multigene family; mrna; rt-pcr; osteosarcoma cell; hla a2 antigen; sarcoma cell; histiocytoma; ssx; human; article; ssx antigen; ssx 1 antigen; ssx 2 antigen; ssx 3 antigen; ssx 4 antigen; ssx 5 antigen
Journal Title: Cancer Immunity
Volume: 3
ISSN: 1424-9634
Publisher: Academy of Cancer Immunology  
Date Published: 2003-10-09
Start Page: 1
End Page: 8
Language: English
PROVIDER: scopus
PUBMED: 14533943
Notes: Export Date: 12 September 2014 -- Source: Scopus