Clinically inapparent invasive vulvar carcinoma in an area of persistent Paget's disease: A case report Journal Article


Authors: Awtrey, C. S.; Marshall, D. S.; Soslow, R. A.; Chi, D. S.
Article Title: Clinically inapparent invasive vulvar carcinoma in an area of persistent Paget's disease: A case report
Abstract: Background. Invasive vulvar carcinoma is reported to occur in 5 to 20% of patients with vulvar Paget's disease. We report a case in which a clinically inapparent invasive lesion was discovered on reexcision of microscopically persistent vulvar Paget's disease. Case. A 58-year-old woman presented with a diagnosis of vulvar Paget's disease. A wide local excision of the lesion was performed and pathologic analysis revealed microscopic Paget's disease at two of the margins. The patient returned for a follow-up 4 months later and a vulvar biopsy revealing persistent Paget's cells was obtained from the area of the prior microscopically positive surgical margin. A reexcision was performed from the normal-appearing vulva and invasive vulvar carcinoma was noted in this specimen. Conclusion. This case demonstrates several concerning aspects of this disease, most important of which is that the clinically apparent lesion did not contain the clinically significant invasive lesion. Invasive vulvar carcinoma may occur in association with microscopically persistent vulvar Paget's disease, a condition often encountered after primary treatment with wide local excision. © 2003 Elsevier Science (USA). All rights reserved.
Keywords: adult; controlled study; human tissue; middle aged; clinical feature; disease course; histopathology; case report; disease association; recurrence; biopsy; invasive carcinoma; gynecologic surgery; vulva carcinoma; vulvar neoplasms; paget skin disease; paget's disease, extramammary; humans; human; female; priority journal; article; vulvar adenocarcinoma; vulvar paget's disease
Journal Title: Gynecologic Oncology
Volume: 88
Issue: 3
ISSN: 0090-8258
Publisher: Elsevier Inc.  
Date Published: 2003-03-01
Start Page: 440
End Page: 443
Language: English
DOI: 10.1016/s0090-8258(02)00007-0
PUBMED: 12648600
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 12 September 2014 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Christopher Awtrey
    11 Awtrey
  2. Dennis S Chi
    496 Chi
  3. Robert Soslow
    644 Soslow