Florid papillomatosis of the nipple: A study of 51 patients, including nine with mammary carcinoma Journal Article

  

Authors:	Rosen, P. P.; Caicco, J. A.
Article Title:	Florid papillomatosis of the nipple: A study of 51 patients, including nine with mammary carcinoma
Abstract:	The present study was undertaken to review the pathology of florid papillomatosis (FP) of the nipple and to examine the relationship of FP to breast carcinoma. Clinical features of 49 women studied did not differ appreciably from those noted on prior reports, except that in one instance the lesion was probably congenital. Histologically, three distinct growth patterns were found: sclerosing papillomatosis (17 cases), papillomatosis (12 cases), and adenosis (13 cases). In 17 other cases, mixtures of these proliferative patterns were seen. FP with the sclerosing papillomatosis pattern more frequently had areas of focal necrosis in hyperplasia ducts and scattered mitoses, features that might be interpreted as evidence of carcinoma. No prognostic significance can be attributed to these patterns, since all types were cured by excision with follow-up that averaged 8.3 years. Seven of the 49 women had carcinoma in the same breast as FP: Two women had invasive carcinoma that appeared to arise from FP, and four women had concurrent invasive carcinomas that were separate from the FP; the seventh woman developed diffuse intraductal carcinoma 10 years after FP was excised from the same breast. Three of the seven women were also treated for contralateral breast carcinoma. Also reviewed were lesions from two men who had carcinoma arising in FP. One had intraductal carcinoma with Paget's disease and the other had invasive carcinoma. Appreciation of the diverse histological patterns of FP may be helpful in avoiding an erroneous diagnosis of carcinoma. Features indicative of carcinoma arising in FP are Paget's disease and areas of invasion. FP on the nipple is rarely the substrate for mammary carcinoma and is adequately treated by local excision. Coexistence with carcinoma elsewhere in the same or opposite breast occurs often enough to warrant thorough examination of the breasts when FP of the nipple is diagnosed. The risk of subsequent carcinoma following excision of FP appears to be low, but clinical follow-up is prudent.
Keywords:	major clinical study; histopathology; breast; histology; papillomatosis; breast carcinoma; diagnosis; nipple; intraductal carcinoma; paget nipple disease; therapy; human; priority journal; nipple disease
Journal Title:	American Journal of Surgical Pathology
Volume:	10
Issue:	2
ISSN:	0147-5185
Publisher:	Lippincott Williams & Wilkins
Date Published:	1986-02-01
Start Page:	87
End Page:	101
Language:	English
DOI:	10.1097/00000478-198602000-00002
PUBMED:	3006526
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022580938&doi=10.1097%2f00000478-198602000-00002&partnerID=40&md5=1fd42fd7ad5770df15cf9c6aa5208925
Notes:	Article -- Export Date: 18 August 2021 -- Source: Scopus

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