Mu opioid receptors in pain management Journal Article
| Authors: | Pasternak, G.; Pan, Y. X. |
| Article Title: | Mu opioid receptors in pain management |
| Abstract: | Most of the potent analgesics currently in use act through the mu opioid receptor. Although they are classified as mu opioids, clinical experience suggests differences among them. The relative potencies of the agents can vary from patient to patient, as well as the side-effect profiles. These observations, coupled with pharmacological approaches in preclinical models, led to the suggestion of multiple subtypes of mu receptors. The explosion in molecular biology has led to the identification of a single gene encoding mu opioid receptors. It now appears that this gene undergoes extensive splicing, in which a single gene can generate multiple proteins. Evidence now suggests that these splice variants may help explain the clinical variability in responses among patients. Copyright © 2011, Taiwan Society of Anesthesiologists. Published by Elsevier Taiwan LLC. All rights reserved. |
| Keywords: | promoter region; exon; drug tolerability; review; drug safety; nonhuman; binding affinity; gene targeting; pain; carboxy terminal sequence; genetic variability; drug potency; molecular cloning; amino acid sequence; messenger rna; alternative splicing; alternative rna splicing; drug dependence; methadone; morphine; respiration depression; analgesics, opioid; molecular biology; guanine nucleotide binding protein; analgesia; mu opiate receptor; receptor binding; rna splicing; fentanyl; diamorphine; enkephalin[2,5 dextro penicillamine]; analgesic activity; gastrointestinal transit; levorphanol; delta opiate receptor; 3,4 dichloro n methyl n [2 (1 pyrrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate; naloxone benzoylhydrazone; binding assay; pharmacogenomics; dynorphin a; enkephalin; ethylketazocine; kappa opiate receptor; naloxonazine; nociceptin |
| Journal Title: | Acta Anaesthesiologica Taiwanica |
| Volume: | 49 |
| Issue: | 1 |
| ISSN: | 1875-4597 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2011-03-01 |
| Start Page: | 21 |
| End Page: | 25 |
| Language: | English |
| DOI: | 10.1016/j.aat.2010.12.008 |
| PROVIDER: | scopus |
| PUBMED: | 21453899 |
| PMCID: | PMC4014005 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 23 June 2011" - "CODEN: AATCC" - "Source: Scopus" |
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