Combination of epitope-optimized DNA vaccination and passive infusion of monoclonal antibody against HER2/neu leads to breast tumor regression in mice Journal Article


Authors: Orlandi, F.; Guevara-Patiño, J. A.; Merghoub, T.; Wolchok, J. D.; Houghton, A. N.; Gregor, P. D.
Article Title: Combination of epitope-optimized DNA vaccination and passive infusion of monoclonal antibody against HER2/neu leads to breast tumor regression in mice
Abstract: HER2/neu is an oncogene amplified and over-expressed in 20-30% of breast adenocarcinomas. Treatment with the humanized monoclonal antibody trastuzumab has shown efficacy in combination with cytotoxic agents, although resistance occurs over time. Novel approaches are needed to further increase antibody efficacy. In this study, we provide evidence in a mouse breast cancer therapeutic tumor model that the combination of active immunization with a modified HER2/neu DNA vaccine and passive infusion of an anti-HER2/neu monoclonal antibody leads to significant regression of established tumors. Our data indicate that combination therapy with a HER2/neu DNA vaccine and trastuzumab may have clinical activity in breast cancer patients. © 2011 Elsevier Ltd.
Keywords: controlled study; nonhuman; mouse; animal tissue; breast cancer; epidermal growth factor receptor 2; animal experiment; animal model; monoclonal antibody; cancer inhibition; cancer regression; immunotherapy; cancer immunization; epitope; dna vaccine; trastuzumab; active immunization; her2/neu; passive immunization
Journal Title: Vaccine
Volume: 29
Issue: 20
ISSN: 0264-410X
Publisher: Elsevier Inc.  
Date Published: 2011-05-09
Start Page: 3646
End Page: 3654
Language: English
DOI: 10.1016/j.vaccine.2011.03.017
PROVIDER: scopus
PUBMED: 21435405
DOI/URL:
Notes: --- - "Export Date: 23 June 2011" - "CODEN: VACCD" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Polly Gregor
    29 Gregor
  2. Jedd D Wolchok
    701 Wolchok
  3. Taha Merghoub
    225 Merghoub
  4. Alan N Houghton
    288 Houghton