Pelvic nodal radiotherapy in patients with unfavorable intermediate and high-risk prostate cancer: Evidence, rationale, and future directions Journal Article
| Authors: | Morikawa, L. K.; Roach, M. 3rd |
| Article Title: | Pelvic nodal radiotherapy in patients with unfavorable intermediate and high-risk prostate cancer: Evidence, rationale, and future directions |
| Abstract: | Over the past 15 years, there have been three major advances in the use of external beam radiotherapy in the management of men with clinically localized prostate made. They include: (1) image guided (IG) three-dimensional conformal/intensity modulated radiotherapy; (2) radiation dose escalation; and (3) androgen deprivation therapy. To date only the last of these three advances have been shown to improve overall survival. The presence of occult pelvic nodal involvement could explain the failure of increased conformality and dose escalation to prolong survival, because the men who appear to be at the greatest risk of death from clinically localized prostate cancer are those who are likely to have lymph node metastases. This review discusses the evidence for prophylactic pelvic nodal radiotherapy, including the key trials and controversies surrounding this issue. © 2011 Elsevier Inc. |
| Keywords: | cancer survival; overall survival; review; three dimensional; intensity modulated radiation therapy; radiation dose; lymph node metastasis; pelvis lymph node; radiotherapy; prostate cancer; prophylaxis; external beam radiotherapy; computer assisted radiotherapy; androgen deprivation therapy; diseases; lymph node irradiation; high-risk; clinical trial (topic); occult cancer; unfavorable intermediate-risk; whole pelvic radiotherapy |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 80 |
| Issue: | 1 |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2011-05-01 |
| Start Page: | 6 |
| End Page: | 16 |
| Language: | English |
| DOI: | 10.1016/j.ijrobp.2010.11.074 |
| PROVIDER: | scopus |
| PUBMED: | 21481721 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: IOBPD" - "Source: Scopus" |
