Younger adults with acute myeloid leukemia in remission for ≥3 years have a high likelihood of cure: The ECOG experience in over 1200 patients Journal Article

   

Authors:	Watts, J. M.; Wang, X. V.; Litzow, M. R.; Luger, S. M.; Lazarus, H. M.; Cassileth, P. A.; Fernandez, H. F.; Douer, D.; Zickl, L.; Paietta, E.; Rowe, J. M.; Tallman, M. S.
Article Title:	Younger adults with acute myeloid leukemia in remission for ≥3 years have a high likelihood of cure: The ECOG experience in over 1200 patients
Abstract:	We examined 1229 younger patients with acute myeloid leukemia who achieved CR1 on Eastern Cooperative Oncology Group trials. We defined late relapse as occurring after ≥3 years of CR1. With median follow-up of 11.3 years, there were 14 late relapses (1.1% of CR1 patients; 3.3% of 3-year CR1 patients). Eight achieved second CR and median overall survival after late relapse was 3.2 years. Most patients tested (9/11) had a normal karyotype at diagnosis; none had new cytogenetic abnormalities at relapse. Late relapse is rare and nearly all 3-year CR1 patients are cured. If late relapse occurs, outcomes are relatively favorable. © 2014 Elsevier Ltd.
Keywords:	adolescent; adult; cancer survival; controlled study; middle aged; young adult; acute granulocytic leukemia; major clinical study; overall survival; follow up; cytogenetics; cancer mortality; high risk patient; leukocyte count; leukemia relapse; health care organization; karyotype; outcomes; clinical trials; leukemia remission; acute myeloid leukemia; late relapse; normal cytogenetics; human; male; female; priority journal; article; eastern cooperative oncology group
Journal Title:	Leukemia Research
Volume:	38
Issue:	8
ISSN:	0145-2126
Publisher:	Elsevier Ltd
Date Published:	2014-08-01
Start Page:	901
End Page:	906
Language:	English
DOI:	10.1016/j.leukres.2014.05.018
PROVIDER:	scopus
PUBMED:	24986381
PMCID:	PMC4326112
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84904577671&partnerID=40&md5=10e283e0336713d717043f9cdf916647
Notes:	Export Date: 2 September 2014 -- CODEN: LERED -- Source: Scopus

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