Translational implications of somatic genomics in acute myeloid leukaemia Journal Article
| Authors: | Meyer, S. C.; Levine, R. L. |
| Article Title: | Translational implications of somatic genomics in acute myeloid leukaemia |
| Abstract: | Acute myeloid leukaemia (AML) is caused by acquired somatic mutations in haemopoietic progenitors. Understanding of the genetic basis of the disease has greatly benefited from the use of DNA sequencing to identify novel disease alleles. Chromosomal aberrations are known to drive AML and are the mainstay of risk classification. Mutations in FLT3, NPM1, and CEBPA provide prognostic information and have been integrated into clinical diagnostics and clinical practice. Comprehensive next-generation sequencing studies have given insight into AML pathogenesis. These insights are leading to refined prognostic stratification and suggest differentially tailored treatment based on integrated genetic profiles. Translation of comprehensive genetic analyses to the clinical setting is the next challenge, to enable genotype-specific therapies for patients with AML and other malignant disorders. © 2014 Elsevier Ltd. |
| Keywords: | unclassified drug; oncoprotein; acute granulocytic leukemia; gene mutation; gene translocation; review; nonhuman; cohesin; stem cell factor receptor; genetic association; protein p53; carcinogenesis; molecular cloning; chromosome aberration; oncogene; dna; gene identification; genomics; dna sequence; ras protein; wt1 protein; cancer classification; spliceosome; oncogene ras; tet2 gene; isocitrate dehydrogenase; protein tet2; transcription factor runx1; dna methyltransferase 3a; kit gene; cd135 antigen; nucleophosmin; mixed lineage leukemia protein; translation regulation; protein asxl1; ccaat enhancer binding protein alpha; chromosome inversion; tp53 gene; next generation sequencing; cancer prognosis; dnmt3a gene; npm1 gene; flt3 gene; mll gene; phf6 gene; wt1 gene; human; priority journal; protein phf6; cepra gene; cohesin gene; runx1 gene |
| Journal Title: | Lancet Oncology |
| Volume: | 15 |
| Issue: | 9 |
| ISSN: | 1470-2045 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2014-08-01 |
| Start Page: | e382 |
| End Page: | e394 |
| Language: | English |
| DOI: | 10.1016/s1470-2045(14)70008-7 |
| PROVIDER: | scopus |
| PUBMED: | 25079101 |
| DOI/URL: | |
| Notes: | Export Date: 2 September 2014 -- CODEN: LOANB -- Source: Scopus |
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