Molecular genetics of acute myeloid leukemia: Clinical implications and opportunities for integrating genomics into clinical practice Journal Article


Author: Abdel-Wahab, O.
Article Title: Molecular genetics of acute myeloid leukemia: Clinical implications and opportunities for integrating genomics into clinical practice
Abstract: Advances in sequencing technologies have led to the discovery of a series of mutations in a sizeable proportion of patients with acute myeloid leukemia (AML) over the last 10 years. Clinical correlative studies are now beginning to decipher the clinical importance, prevalence and potential prognostic significance of these mutations in AML but few studies have assessed the clinical implications of these mutations in a comprehensive fashion. Nonetheless, mutations in DNMT3A, TET2, and ASXL1 are emerging as important adverse prognosticators in subsets of patients with AML independent of FLT3 mutations whereas mutations in IDH2 at residue 140 are potential predictors of improved outcome in AML. Further improvements in cost, throughput, and clinical validation of second-generation sequencing technologies may allow for clinical implementation of comprehensive genetic profiling in the clinical care of AML patients. © W. S. Maney & Son Ltd 2012.
Keywords: acute granulocytic leukemia; gene mutation; gene sequence; mutation; dna-binding proteins; leukemia, myeloid, acute; proto-oncogene proteins; clinical feature; validation process; molecular genetics; genetic analysis; clinical practice; gene; prevalence; genotype; cytogenetics; health care cost; patient care; clinical study; genomics; clinical effectiveness; genetic risk; repressor proteins; dna (cytosine-5-)-methyltransferase; predictive value; tet2 gene; gene expression regulation, leukemic; isocitrate dehydrogenase; aml; asxl1 gene; tet2; idh2 gene; asxl1; idh1/2; dna integration; fms-like tyrosine kinase 3; dnmt3a; high throughput sequencing; dnmt3a gene; flt3 gene
Journal Title: Hematology
Volume: 17
Issue: Suppl. 1
ISSN: 1024-5332
Publisher: Maney Publishing  
Date Published: 2012-04-01
Start Page: S39
End Page: S42
Language: English
DOI: 10.1179/102453312x13336169155411
PROVIDER: scopus
PUBMED: 22507776
DOI/URL:
Notes: --- - "Export Date: 1 May 2012" - "CODEN: HMATF" - "Source: Scopus"
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